SUV39H1 Antibody, clone MG44 | EMD Millipore 05-615 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SUV39H1 Antibody, clone MG44

catalog :

05-615

quantity :

200 μL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MG44

The same clone is also sold as:

Active Motif: 39785

reactivity :

human

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 11

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; loading ... western blot; human; 1:500; loading ...; fig 5a	Altieri F, Di Stadio C, Federico A, Miselli G, De Palma M, Rippa E, et al. Epigenetic alterations of gastrokine 1 gene expression in gastric cancer. Oncotarget. 2017;8:16899-16911 pubmed publisher
western blot; human; fig 2	Hossain M, Stillman B. Opposing roles for DNA replication initiator proteins ORC1 and CDC6 in control of Cyclin E gene transcription. elife. 2016;5: pubmed publisher
chromatin immunoprecipitation; human; fig 6	Varshney D, Vavrova Anderson J, Oler A, Cowling V, Cairns B, White R. SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation. Nat Commun. 2015;6:6569 pubmed publisher
immunoprecipitation; human western blot; human; fig 6	Mund A, Schubert T, Staege H, Kinkley S, Reumann K, Kriegs M, et al. SPOC1 modulates DNA repair by regulating key determinants of chromatin compaction and DNA damage response. Nucleic Acids Res. 2012;40:11363-79 pubmed publisher
chromatin immunoprecipitation; human	Lee C, Hung H, Hung P, Shieh Y. Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer. Mol Cancer. 2010;9:64 pubmed publisher
	Kamiunten T, Ideno H, Shimada A, Nakamura Y, Kimura H, Nakashima K, et al. Coordinated expression of H3K9 histone methyltransferases during tooth development in mice. Histochem Cell Biol. 2015;143:259-66 pubmed publisher
	Zhang Z, Liu Y, Li S, Guo L, Zhao Y, Qian S, et al. Suv39h1 mediates AP-2?-dependent inhibition of C/EBP? expression during adipogenesis. Mol Cell Biol. 2014;34:2330-8 pubmed publisher
	Lee M, Kuo Y, Chou W, Hou H, Hsiao M, Tien H. Gfi-1 is the transcriptional repressor of SOCS1 in acute myeloid leukemia cells. J Leukoc Biol. 2014;95:105-15 pubmed publisher
	Lee J, Kim K. DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells. Biochem Biophys Res Commun. 2013;438:647-52 pubmed publisher
	Villeneuve L, Kato M, Reddy M, Wang M, Lanting L, Natarajan R. Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes. 2010;59:2904-15 pubmed publisher
	Brasacchio D, Okabe J, Tikellis C, Balcerczyk A, George P, Baker E, et al. Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. Diabetes. 2009;58:1229-36 pubmed publisher

product information

Catalog Number :

05-615

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SUV39H1 Antibody, clone MG44

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

O43463

Host Name :

Mouse

Antigen :

SUV39H1

Clone :

MG44

Conjugate :

Ascites

Isotype :

IgG

Product Description :

Anti-SUV39H1 Antibody, clone MG44

Cross Reactivity :

Human;Mouse

Background :

Post -translational modification of histones, such as phosphorylation, acetylation, and methylation, are crucial for chromatin remodeling. SUV39H1 and Suv39h1 are the human and mouse homologs of Drosophila Su(var)3-9 protein, respectively. These proteins selectively methylate histone H3 at lysine 9 creating a high-affinity binding site for the HP1 proteins (heterochromatin protein 1). HP1 proteins are known to interact with transcription suppressor proteins, suggesting that the interactions with SUV39H1 and methylated histone H3 mediate a silence effect on the transcription of target genes. Furthermore, over-expression of SUV39H1 in HeLa cells causes a redistribution of endogenous HP1 proteins and growth retardation, suggesting that SUV39H1-mediated modulation of heterochromatin can impair cell cycle progression.

ALT Names :

KMT1A

Immunogen :

MBP fusion protein corresponding to residues 1-412 of human SUV39H1

Specificity :

Recognizes SUV39H1.

Package Size :

200 μL

Uses :

Immunoprecipitation;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.