Tie2/TEK Antibody, clone Ab33 | EMD Millipore 05-584 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tie2/TEK Antibody, clone Ab33

catalog :

05-584

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ab33

The same clone is also sold as:

Cell Signaling Technology: 4224

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation, western blot knockout validation

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; fig 1b western blot; mouse; fig 1b	Gong H, Liu M, Klomp J, Merrill B, Rehman J, Malik A. Method for Dual Viral Vector Mediated CRISPR-Cas9 Gene Disruption in Primary Human Endothelial Cells. Sci Rep. 2017;7:42127 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 6a	Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, et al. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain Res. 2016;1650:31-40 pubmed publisher
western blot; mouse	Fehring V, Schaeper U, Ahrens K, Santel A, Keil O, Eisermann M, et al. Delivery of therapeutic siRNA to the lung endothelium via novel Lipoplex formulation DACC. Mol Ther. 2014;22:811-20 pubmed publisher
	Saulle E, Guerriero R, Petronelli A, Coppotelli E, Gabbianelli M, Morsilli O, et al. Autocrine role of angiopoietins during megakaryocytic differentiation. PLoS ONE. 2012;7:e39796 pubmed publisher
	Makinde T, Agrawal D. Increased expression of angiopoietins and Tie2 in the lungs of chronic asthmatic mice. Am J Respir Cell Mol Biol. 2011;44:384-93 pubmed publisher
	Huang J, Bae J, Tsai J, Kadenhe Chiweshe A, Papa J, Lee A, et al. Angiopoietin-1/Tie-2 activation contributes to vascular survival and tumor growth during VEGF blockade. Int J Oncol. 2009;34:79-87 pubmed
	Dallabrida S, Ismail N, Pravda E, Parodi E, Dickie R, Durand E, et al. Integrin binding angiopoietin-1 monomers reduce cardiac hypertrophy. FASEB J. 2008;22:3010-23 pubmed publisher
	Parikh S, Mammoto T, Schultz A, Yuan H, Christiani D, Karumanchi S, et al. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 2006;3:e46 pubmed

product information

Catalog Number :

05-584

Subcategory :

Cell Signaling

Product Name :

Anti-Tie2/TEK Antibody, clone Ab33

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q02763

Host Name :

Mouse

Antigen :

Tie2/TEK

Clone :

clone Ab33

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Tie2/TEK Antibody, clone Ab33

Cross Reactivity :

Human;Mouse;Rat;Pig

Background :

TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis.

ALT Names :

CD202b antigen;TEK tyrosine kinase, endothelial;Tunica interna endothelial cell kinase;Tyrosine-protein kinase receptor TEK;Tyrosine-protein kinase receptor TIE-2;p140 TEK;soluble TIE2 variant 1;soluble TIE2 variant 2venous malformations, multiple cutaneous and mucosal

Immunogen :

Fusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells. Clone Ab33

Specificity :

Recognizes Tie2/TEK, Mr 145kDa

Package Size :

200 μg

Uses :

Western Blotting;Immunoprecipitation;Immunohistochemistry

Storage :

Stable for 1 year at from date of receipt.