Notch 1 Antibody, clone 8G10 | EMD Millipore 05-557 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Notch 1 Antibody, clone 8G10

catalog :

05-557

quantity :

200 μL

clonality :

monoclonal

host :

Syrian golden hamster

conjugate :

nonconjugated

clone name :

8G10

The same clone is also sold as:

Santa Cruz Biotechnology: sc-32756

reactivity :

mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

citations: 24

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:500; loading ...; fig 5a	Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher
flow cytometry; rat	Boopathy A, Che P, Somasuntharam I, Fiore V, Cabigas E, Ban K, et al. The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation. Biomaterials. 2014;35:8103-12 pubmed publisher
	Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T. Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells. Oncotarget. 2014;5:7540-8 pubmed
	Wang S, Sun W, Zhao Y, McEachern D, Meaux I, BarriÃ¨re C, et al. SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res. 2014;74:5855-65 pubmed publisher
	Chou C, Huang N, Jhuang S, Pan H, Peng N, Cheng J, et al. Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions. PLoS ONE. 2014;9:e93934 pubmed publisher
	Guerzoni C, Amatori S, Giorgi L, Manara M, Landuzzi L, Lollini P, et al. An aza-macrocycle containing maltolic side-arms (maltonis) as potential drug against human pediatric sarcomas. BMC Cancer. 2014;14:137 pubmed publisher
	Sun F, Mao X, Xie L, Ding M, Shao B, Jin K. Notch1 signaling modulates neuronal progenitor activity in the subventricular zone in response to aging and focal ischemia. Aging Cell. 2013;12:978-87 pubmed publisher
	Huang B, Ray P, Iwasaki K, Tsuji Y. Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. FASEB J. 2013;27:3763-74 pubmed publisher
	Brizuela L, Ader I, Mazerolles C, Bocquet M, Malavaud B, Cuvillier O. First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. Mol Cancer Ther. 2012;11:1841-51 pubmed publisher
	Leopoldino A, Squarize C, Garcia C, Almeida L, Pestana C, Sobral L, et al. SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 2012;48:1106-13 pubmed publisher
	Crose L, Etheridge K, Chen C, Belyea B, Talbot L, Bentley R, et al. FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. Clin Cancer Res. 2012;18:3780-90 pubmed publisher
	Hou X, Tashima Y, Stanley P. Galactose differentially modulates lunatic and manic fringe effects on Delta1-induced NOTCH signaling. J Biol Chem. 2012;287:474-83 pubmed publisher
	Radi E, Formichi P, Di Maio G, Battisti C, Federico A. Oxidative stress-induced apoptosis in two patients with Alagille syndrome. J Neurol Sci. 2011;308:49-56 pubmed publisher
	Leonelli M, Martins D, Britto L. TRPV1 receptors modulate retinal development. Int J Dev Neurosci. 2011;29:405-13 pubmed publisher
	Zhou Y, Feng X, Koh D. Activation of cell death mediated by apoptosis-inducing factor due to the absence of poly(ADP-ribose) glycohydrolase. Biochemistry. 2011;50:2850-9 pubmed publisher
	Dindot S, Piccolo P, Grove N, Palmer D, Brunetti Pierri N. Intrathecal injection of helper-dependent adenoviral vectors results in long-term transgene expression in neuroependymal cells and neurons. Hum Gene Ther. 2011;22:745-51 pubmed publisher
	Kim E, Teh S, Yang J, Chow M, Teh H. TNFR2-deficient memory CD8 T cells provide superior protection against tumor cell growth. J Immunol. 2009;183:6051-7 pubmed publisher
	Shawgo M, Shelton S, Robertson J. Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells. J Biol Chem. 2009;284:33447-55 pubmed publisher
	Shelton S, Shawgo M, Matthews S, Lu Y, Donnelly A, Szabla K, et al. KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells. Mol Pharmacol. 2009;76:1314-22 pubmed publisher
	Chen L, Redkar S, Bearss D, Wierda W, Gandhi V. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2009;114:4150-7 pubmed publisher
	Clement C, Dandepally S, Williams A, Ibeanu G. A synthetic analog of verbenachalcone potentiates NGF-induced neurite outgrowth and enhances cell survival in neuronal cell models. Neurosci Lett. 2009;459:157-61 pubmed publisher
	Zaghloul N, Hernandez S, Bae J, Huang J, Fisher J, Lee A, et al. Vascular endothelial growth factor blockade rapidly elicits alternative proangiogenic pathways in neuroblastoma. Int J Oncol. 2009;34:401-7 pubmed
	Stahl M, Uemura K, Ge C, Shi S, Tashima Y, Stanley P. Roles of Pofut1 and O-fucose in mammalian Notch signaling. J Biol Chem. 2008;283:13638-51 pubmed publisher
	Preyer M, Shu C, Wang J. Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ. 2007;14:1139-48 pubmed

product information

Catalog Number :

05-557

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Notch 1 Antibody, clone 8G10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q5SXM3

Host Name :

Syrian Hamster

Antigen :

Notch 1

Clone :

8G10

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Notch 1 Antibody, clone 8G10

Cross Reactivity :

Mouse;Rat

Background :

The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).

Immunogen :

Residues 1299-1492 of murine notch 1

Specificity :

Recognizes Notch 1.

Package Size :

200 μL

Uses :

Flow Cytometry;Immunocytochemistry;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.