| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 1a
- western blot; human; 1:3000; loading ...; fig 1c
| Jeong W, Park J, Kim W, Ro E, Jeon S, Lee S, et al. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nat Commun. 2019;10:295 pubmed publisher |
- western blot; human; loading ...; fig 3f
| Bigenzahn J, Collu G, Kartnig F, Pieraks M, Vladimer G, Heinz L, et al. LZTR1 is a regulator of RAS ubiquitination and signaling. Science. 2018;362:1171-1177 pubmed publisher |
- western blot; human; loading ...; fig 4f
- western blot; mouse; loading ...; fig 2b, 3e
| Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Nat Med. 2018;24:954-960 pubmed publisher |
- immunohistochemistry - paraffin section; human; loading ...; fig s2
- flow cytometry; human; loading ...; tbl 1
- immunoprecipitation; human; loading ...; tbl 1
- immunocytochemistry; human; loading ...; tbl 1
- ELISA; human; loading ...; tbl 1
- western blot; human; fig 1b
| Waters A, Ozkan Dagliyan I, Vaseva A, Fer N, Strathern L, Hobbs G, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Sci Signal. 2017;10: pubmed publisher |
- western blot; human; loading ...; fig 7e
| Jiang X, Bao Y, Liu H, Kou X, Zhang Z, Sun F, et al. VPS34 stimulation of p62 phosphorylation for cancer progression. Oncogene. 2017;36:6850-6862 pubmed publisher |
- western blot; human; loading ...; fig 6a
| Eppler F, Quast T, Kolanus W. Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion. PLoS ONE. 2017;12:e0172443 pubmed publisher |
- western blot; human; 1:2000; loading ...; fig 4a, 5a
| Huang C, Huang S, Chien C, Lee H, Yang S, Chang C, et al. Impact of microsatellite status on chemotherapy for colorectal cancer patients with KRAS or BRAF mutation. Oncol Lett. 2016;12:4427-4434 pubmed publisher |
- western blot; human; loading ...; fig 5a
| Li Y, Buijs Gladdines J, Cant Barrett K, Stubbs A, Vroegindeweij E, Smits W, et al. IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study. PLoS Med. 2016;13:e1002200 pubmed publisher |
- western blot; human; loading ...; fig 1a
- western blot; hamsters; loading ...; fig 1d
- western blot; mouse; loading ...; fig 1a
| Battram A, Durrant T, Agbani E, Heesom K, Paul D, Piatt R, et al. The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling. J Biol Chem. 2017;292:1691-1704 pubmed publisher |
- western blot; mouse; loading ...; fig 6c
| Sakata K, Araki K, Nakano H, Nishina T, Komazawa Sakon S, Murai S, et al. Novel method to rescue a lethal phenotype through integration of target gene onto the X-chromosome. Sci Rep. 2016;6:37200 pubmed publisher |
- western blot; human; loading ...; fig 4
| Madureira P, Bharadwaj A, Bydoun M, Garant K, O Connell P, Lee P, et al. Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10. Oncotarget. 2016;7:47720-47737 pubmed publisher |
- western blot; mouse; loading ...; fig 1e
| Cant Barrett K, Spijkers Hagelstein J, Buijs Gladdines J, Uitdehaag J, Smits W, van der Zwet J, et al. MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia. Leukemia. 2016;30:1832-43 pubmed publisher |
- western blot; mouse; 1:2000; fig 4
- western blot; human; 1:2000; fig 1
| White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, et al. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nat Commun. 2016;7:10647 pubmed publisher |
- western blot; human; fig 2a
| Capell B, Drake A, Zhu J, Shah P, Dou Z, Dorsey J, et al. MLL1 is essential for the senescence-associated secretory phenotype. Genes Dev. 2016;30:321-36 pubmed publisher |
- western blot; mouse; fig 4
| Grassilli E, Pisano F, Cialdella A, Bonomo S, Missaglia C, Cerrito M, et al. A novel oncogenic BTK isoform is overexpressed in colon cancers and required for RAS-mediated transformation. Oncogene. 2016;35:4368-78 pubmed publisher |
- western blot; mouse; loading ...; fig 7b
| Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, et al. Kras Is Critical for B Cell Lymphopoiesis. J Immunol. 2016;196:1678-85 pubmed publisher |
- western blot; mouse; fig 1
| Diersch S, Wirth M, Schneeweis C, Jörs S, Geisler F, Siveke J, et al. Kras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells. Oncogene. 2016;35:3880-6 pubmed publisher |
- western blot; human; fig 1
| Ksionda O, Melton A, Bache J, Tenhagen M, Bakker J, Harvey R, et al. RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene. 2016;35:3658-68 pubmed publisher |
- western blot; human; fig 3
| Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015;527:105-9 pubmed publisher |
- western blot; human; 1:1000
| Antic I, Biancucci M, Zhu Y, GIUS D, Satchell K. Site-specific processing of Ras and Rap1 Switch I by a MARTX toxin effector domain. Nat Commun. 2015;6:7396 pubmed publisher |
| Straniero V, Pallavicini M, Chiodini G, Ruggeri P, Fumagalli L, Bolchi C, et al. Farnesyltransferase inhibitors: CAAX mimetics based on different biaryl scaffolds. Bioorg Med Chem Lett. 2014;24:2924-7 pubmed publisher |
| Cipriano R, Miskimen K, Bryson B, Foy C, Bartel C, Jackson M. Conserved oncogenic behavior of the FAM83 family regulates MAPK signaling in human cancer. Mol Cancer Res. 2014;12:1156-65 pubmed publisher |
- western blot; mouse; fig 8
| Gurung B, Muhammad A, Hua X. Menin is required for optimal processing of the microRNA let-7a. J Biol Chem. 2014;289:9902-8 pubmed publisher |
| Kloog Y, Mor A. Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1. Mol Cell Biol. 2014;34:978-88 pubmed publisher |
- immunoprecipitation; human
| Kostenko S, Jensen K, Moens U. Phosphorylation of heat shock protein 40 (Hsp40/DnaJB1) by mitogen-activated protein kinase-activated protein kinase 5 (MK5/PRAK). Int J Biochem Cell Biol. 2014;47:29-37 pubmed publisher |
| Shain A, Salari K, Giacomini C, Pollack J. Integrative genomic and functional profiling of the pancreatic cancer genome. BMC Genomics. 2013;14:624 pubmed publisher |
- western blot; mouse; 1:1000
| Philip B, Roland C, Daniluk J, Liu Y, Chatterjee D, Gomez S, et al. A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice. Gastroenterology. 2013;145:1449-58 pubmed publisher |
- western blot; human; fig 2
| Haeussler D, Pimentel D, Hou X, Burgoyne J, Cohen R, Bachschmid M. Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration. J Biol Chem. 2013;288:15380-9 pubmed publisher |
| Vartanian S, BENTLEY C, Brauer M, Li L, Shirasawa S, Sasazuki T, et al. Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem. 2013;288:2403-13 pubmed publisher |
| Redchuk T, Karasev M, Verkhusha P, Donnelly S, Hülsemann M, Virtanen J, et al. Optogenetic regulation of endogenous proteins. Nat Commun. 2020;11:605 pubmed publisher |
| Johnson C, Lin Y, Reid D, Parker J, Pavlopoulos S, Dischinger P, et al. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep. 2019;28:1538-1550.e7 pubmed publisher |
| Zhang P, He F, Bai J, Yamamoto S, Chen S, Zhang L, et al. Chromatin regulator Asxl1 loss and Nf1 haploinsufficiency cooperate to accelerate myeloid malignancy. J Clin Invest. 2018;128:5383-5398 pubmed publisher |
| Bydoun M, Sterea A, Liptay H, Uzans A, Huang W, Rodrigues G, et al. S100A10, a novel biomarker in pancreatic ductal adenocarcinoma. Mol Oncol. 2018;12:1895-1916 pubmed publisher |
| Jain P, Sethi S, Pratyusha V, Garai P, Naqvi N, Singh S, et al. Ras signaling activates glycosylphosphatidylinositol (GPI) anchor biosynthesis via the GPI-N-acetylglucosaminyltransferase (GPI-GnT) in Candida albicans. J Biol Chem. 2018;293:12222-12238 pubmed publisher |
| Wong G, Zhou J, Liu J, Wu Z, Xu X, Li T, et al. Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med. 2018;24:968-977 pubmed publisher |
| Thinon E, Fernandez J, Molina H, Hang H. Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018;17:1907-1922 pubmed publisher |
| Datta A, Kim H, Lal M, McGee L, Johnson A, Moustafa A, et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. Cancer Lett. 2017;408:73-81 pubmed publisher |
| Martin T, Cook D, Choi M, Li M, Haigis K, Elledge S. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017;20:427-438 pubmed publisher |
| Scavello M, Petlick A, Ramesh R, Thompson V, Lotfi P, Charest P. Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium. J Cell Sci. 2017;130:1545-1558 pubmed publisher |
| Gavin H, Beubier N, Satchell K. The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine. PLoS Pathog. 2017;13:e1006119 pubmed publisher |
| Liu Y, Yang H, Cao J, Jiang Y, Hao J, Xu X, et al. KIAA1522 is a novel prognostic biomarker in patients with non-small cell lung cancer. Sci Rep. 2016;6:24786 pubmed publisher |
| Castellano E, Molina Arcas M, Krygowska A, East P, Warne P, Nicol A, et al. RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression. Nat Commun. 2016;7:11245 pubmed publisher |
| Percher A, Ramakrishnan S, Thinon E, Yuan X, Yount J, Hang H. Mass-tag labeling reveals site-specific and endogenous levels of protein S-fatty acylation. Proc Natl Acad Sci U S A. 2016;113:4302-7 pubmed publisher |
| Roda D, Castillo J, Telechea Fernández M, Gil A, López Rodas G, Franco L, et al. EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells. PLoS ONE. 2015;10:e0130543 pubmed publisher |
| Choo K, Soon Y, Nguyen P, Hiew M, Huang C. MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells. J Biomed Sci. 2014;21:95 pubmed publisher |
| Catanzaro J, Sheshadri N, Pan J, Sun Y, Shi C, Li J, et al. Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun. 2014;5:3729 pubmed publisher |
| Tong J, Lung R, Sin F, Law P, Kang W, Chan A, et al. Characterization of rare transforming KRAS mutations in sporadic colorectal cancer. Cancer Biol Ther. 2014;15:768-76 pubmed publisher |
| Azrak S, Ginel Picardo A, Drosten M, Barbacid M, Santos E. Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. BMC Genomics. 2013;14:731 pubmed publisher |
| Jin Q, Ding W, Mulder K. The TGF? receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGF?1 autoinduction via its association with Ras. J Biol Chem. 2012;287:26453-63 pubmed publisher |
| Cook C, Kim A, Terao S, Gotoh A, Higuchi M. Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer. Cell Death Dis. 2012;3:e258 pubmed publisher |
| Sperka T, Geissler K, Merkel U, Scholl I, Rubio I, Herrlich P, et al. Activation of Ras requires the ERM-dependent link of actin to the plasma membrane. PLoS ONE. 2011;6:e27511 pubmed publisher |
| Charette N, De Saeger C, Lannoy V, Horsmans Y, Leclercq I, Starkel P. Salirasib inhibits the growth of hepatocarcinoma cell lines in vitro and tumor growth in vivo through ras and mTOR inhibition. Mol Cancer. 2010;9:256 pubmed publisher |
| Holden P, Horton W. Crude subcellular fractionation of cultured mammalian cell lines. BMC Res Notes. 2009;2:243 pubmed publisher |
| Kawasaki K, Watabe T, Sase H, Hirashima M, Koide H, Morishita Y, et al. Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells. J Cell Biol. 2008;181:131-41 pubmed publisher |
| Yokoyama T, Takano K, Yoshida A, Katada F, Sun P, Takenawa T, et al. DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation. J Cell Biol. 2007;177:781-93 pubmed |
| Marti F, Garcia G, Lapinski P, Macgregor J, King P. Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells. J Exp Med. 2006;203:281-7 pubmed |
| Bivona T, Wiener H, Ahearn I, Silletti J, Chiu V, Philips M. Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion. J Cell Biol. 2004;164:461-70 pubmed |
