Cbl Antibody, clone 7G10 | EMD Millipore 05-440 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cbl Antibody, clone 7G10

catalog :

05-440

quantity :

200 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7G10

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4a	Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
western blot; mouse; fig 3	Boding L, Hansen A, Meroni G, Johansen B, Braunstein T, Bonefeld C, et al. Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells. Eur J Immunol. 2014;44:3109-18 pubmed publisher
	Gustin S, Thien C, Langdon W. Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells. J Immunol. 2006;177:5980-9 pubmed

product information

Catalog Number :

05-440

Subcategory :

Protein Trafficking

Product Name :

Anti-Cbl Antibody, clone 7G10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P22681

Host Name :

Mouse

Antigen :

Cbl

Clone :

7G10

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Cbl Antibody, clone 7G10

Cross Reactivity :

Human;Mouse;Rat

Background :

Casitas B-lineage lymphoma (Cbl), is an oncogene which causes pre B-cell lymphomas. It participates in the regulation of cell signaling and has the ability to interact with many proteins such as receptor/non-receptor PTK's, structural proteins, and novel proteins that are not well understood. Diseases associated with Cbl are autoimmune diseases, diabetes, and leukemia. By modifying Cbl's ability to bind to oncogenic proteins, Cbl may be developed into an anti-cancer tool and in the near future used in therapeutic intervention.

ALT Names :

Cas-Br-M (murine) ecotropic retroviral transforming sequence ;Casitas B-lineage lymphoma proto-oncogene;Proto-oncogene c-CBL;RING finger protein 55;Signal transduction protein CBL ;oncogene CBL2

Immunogen :

GST fusion protein corresponding to residues 878-906 of human Cbl

Specificity :

Antibody recognizes amino acids 878-906 on human Cbl

Package Size :

200 µg

Uses :

Immunoprecipitation;Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8ºC from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.