Syk Antibody, clone 4D10.1 | EMD Millipore 05-434 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Syk Antibody, clone 4D10.1

catalog :

05-434

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4D10.1

The same clone is also sold as:

LifeSpan Biosciences: LS-C88078, LS-C88076
Invitrogen: 14-6696-80, 17-6696-42, 14-6696-82, 12-6696-42, 14-6696-37, 14-6696-95, 53-6696-41, 53-6696-42

reactivity :

African green monkey, human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; African green monkey; 1:500	Stebbing R, Irvin S, Rivera Serrano E, Boehme K, Ikizler M, Yoder J, et al. An ITAM in a nonenveloped virus regulates activation of NF-?B, induction of beta interferon, and viral spread. J Virol. 2014;88:2572-83 pubmed publisher
western blot; mouse; fig s7b	Jabara H, McDonald D, Janssen E, Massaad M, Ramesh N, Borzutzky A, et al. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012;13:612-20 pubmed publisher
	Flierl U, Nero T, Lim B, Arthur J, Yao Y, Jung S, et al. Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. J Exp Med. 2015;212:129-37 pubmed publisher
	Agrawal R, Wisniewski J, Yu M, Kennedy J, Platts Mills T, Heymann P, et al. Infection with human rhinovirus 16 promotes enhanced IgE responsiveness in basophils of atopic asthmatics. Clin Exp Allergy. 2014;44:1266-73 pubmed publisher
	Fruchon S, Kheirallah S, Al Saati T, Ysebaert L, Laurent C, Leseux L, et al. Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis. Leukemia. 2012;26:795-805 pubmed publisher
	Jones M, Shawe Taylor A, Williams C, Poole A. Characterization of a novel focal adhesion kinase inhibitor in human platelets. Biochem Biophys Res Commun. 2009;389:198-203 pubmed publisher
	Shrimpton C, Borthakur G, Larrucea S, Cruz M, Dong J, Lopez J. Localization of the adhesion receptor glycoprotein Ib-IX-V complex to lipid rafts is required for platelet adhesion and activation. J Exp Med. 2002;196:1057-66 pubmed

product information

Catalog Number :

05-434

Subcategory :

Cell Signaling

Product Name :

Anti-Syk Antibody, clone 4D10.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P43405

Host Name :

Mouse

Antigen :

Syk

Clone :

4D10.1

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-Syk Antibody, clone 4D10.1

Cross Reactivity :

Human

Background :

Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

ALT Names :

Spleen tyrosine kinase

Immunogen :

Synthetic peptide corresponding to residues 313-339 of human Syk conjugated to KLH.

Specificity :

Recognizes Syk.

Package Size :

100 μg

Uses :

Immunoprecipitation;Enzyme Assay;Western Blotting

Storage :

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.