RhoGAP p190 Antibody, clone D2D6 | EMD Millipore 05-378 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

RhoGAP p190 Antibody, clone D2D6

catalog :

05-378

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D2D6

reactivity :

human, mouse

application :

western blot, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human	Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
immunoprecipitation; mouse	Kerrisk M, Greer C, Koleske A. Integrin ?3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior. J Neurosci. 2013;33:6742-52 pubmed publisher
	Mei H, Ho M, Yung L, Wu Z, Ip N, Wong Y. Expression of G?(z) in C2C12 cells restrains myogenic differentiation. Cell Signal. 2011;23:389-97 pubmed publisher
	Tripathi B, Zelenka P. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Mol Cell Biol. 2009;29:6488-99 pubmed publisher

product information

Catalog Number :

05-378

Subcategory :

Cell Signaling

Product Name :

Anti-RhoGAP p190 Antibody, clone D2D6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q07960

Host Name :

Mouse

Antigen :

RhoGAP p190

Clone :

D2D6

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-RhoGAP p190 Antibody, clone D2D6

Cross Reactivity :

Human;Mouse;Rat;Monkey

Background :

RhoGAP p190 (Rho GTPase Activating Protein 5, ARHGAP5), like other RhoGAPs, stimulates the intrinsic GTPases activity of Rho, Rac, and Cdc42, but shows definite preference for Rho. RhoGAP p190 contains an N-terminal GTPase domain and a C-terminal RhoGAP domain. The activity of RhoGAP p190 is known to be regulated by phosphorylation, by kinases such as Src that is stimulated by growth factor signaling or cell attachment and phosphorylate RhoGAP p190 in its central region. This ultimately leads to reduced RHO-GTP and decreased stress fibers.

ALT Names :

CDC42 GTPase-activating protein;GTPase-activating protein rhoOGAP;Rho GTPase activating protein 1;Rho-related small GTPase protein activator;Rho-type GTPase-activating protein 1

Immunogen :

GST-fusion protein to amino acids 180-610 of rat p190 RhoGAP.

Specificity :

Recognizes RhoGAP, MW ~190kDa.

Package Size :

200 μg

Uses :

Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.