This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Na+/K+ ATPase α-1 Antibody, clone C464.6
catalog :
05-369
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
C464.6

The same clone is also sold as:
reactivity :
human, mouse, rat, dogs, pigs , domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 90
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1e
Massa L pez D, Thelen M, Stahl F, Thiel C, Linhorst A, Sylvester M, et al. The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP. elife. 2019;8: pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 2f
Ullrich F, Blin S, Lazarow K, Daubitz T, von Kries J, Jentsch T. Identification of TMEM206 proteins as pore of PAORAC/ASOR acid-sensitive chloride channels. elife. 2019;8: pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4e
He Z, Forest F, Bernard A, Gauthier A, Montard R, Peoc h M, et al. Cutting and Decellularization of Multiple Corneal Stromal Lamellae for the Bioengineering of Endothelial Grafts. Invest Ophthalmol Vis Sci. 2016;57:6639-6651 pubmed publisher
  • immunohistochemistry; human; fig 4
He Z, Forest F, Gain P, Rageade D, Bernard A, Acquart S, et al. 3D map of the human corneal endothelial cell. Sci Rep. 2016;6:29047 pubmed publisher
  • immunocytochemistry; dogs; 1:1000; fig 4
Myers E, Yuan L, Felmlee M, Lin Y, Jiang Y, Pei Y, et al. A novel mutant Na+ /HCO3- cotransporter NBCe1 in a case of compound-heterozygous inheritance of proximal renal tubular acidosis. J Physiol. 2016;594:6267-6286 pubmed publisher
  • western blot; human; 1:500; fig s2
Mannhardt I, Breckwoldt K, Letuffe Brenière D, Schaaf S, Schulz H, Neuber C, et al. Human Engineered Heart Tissue: Analysis of Contractile Force. Stem Cell Reports. 2016;7:29-42 pubmed publisher
  • western blot; human; 1:500; fig 2
Vorup J, Tybirk J, Gunnarsson T, Ravnholt T, Dalsgaard S, Bangsbo J. Effect of speed endurance and strength training on performance, running economy and muscular adaptations in endurance-trained runners. Eur J Appl Physiol. 2016;116:1331-41 pubmed publisher
  • western blot; rat; 1:2000
  • western blot; human; 1:2000; fig 3
Tokhtaeva E, Sun H, Deiss Yehiely N, Wen Y, Soni P, Gabrielli N, et al. The O-glycosylated ectodomain of FXYD5 impairs adhesion by disrupting cell-cell trans-dimerization of Na,K-ATPase β1 subunits. J Cell Sci. 2016;129:2394-406 pubmed publisher
  • western blot; mouse; fig 1c
Denuc A, Núñez E, Calvo E, Loureiro M, Miro Casas E, Guarás A, et al. New protein-protein interactions of mitochondrial connexin 43 in mouse heart. J Cell Mol Med. 2016;20:794-803 pubmed publisher
  • western blot; human; 1:1000; fig 2
Simonin A, Montalbetti N, Gyimesi G, Pujol Giménez J, Hediger M. The Hydroxyl Side Chain of a Highly Conserved Serine Residue Is Required for Cation Selectivity and Substrate Transport in the Glial Glutamate Transporter GLT-1/SLC1A2. J Biol Chem. 2015;290:30464-74 pubmed publisher
  • western blot; human; fig 1
Mohr M, Thomassen M, Girard O, Racinais S, Nybo L. Muscle variables of importance for physiological performance in competitive football. Eur J Appl Physiol. 2016;116:251-62 pubmed publisher
  • western blot; human; fig 3a
Hostrup M, Kalsen A, Onslev J, Jessen S, Haase C, Habib S, et al. Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. J Appl Physiol (1985). 2015;119:475-86 pubmed publisher
  • immunocytochemistry; human
Hsueh Y, Chen H, Wu S, Wang T, Chen J, Ma D. Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways. Mol Ther Methods Clin Dev. 2015;2:15014 pubmed publisher
  • immunoprecipitation; mouse; fig 2
  • western blot; mouse; 1:1000; fig 1
Petrushanko I, Simonenko O, Burnysheva K, Klimanova E, Dergousova E, Mit kevich V, et al. [The ability of cells to adjust to the low oxigen content associated with Na,K-ATPase glutationilation]. Mol Biol (Mosk). 2015;49:175-83 pubmed
  • immunohistochemistry; rat; 1:100; fig 6
Boddu R, Hull T, Bolisetty S, Hu X, Moehle M, Daher J, et al. Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury. Hum Mol Genet. 2015;24:4078-93 pubmed publisher
  • immunohistochemistry; domestic rabbit; fig 4
  • western blot; domestic rabbit; fig 3
Kageyama T, Hayashi R, Hara S, Yoshikawa K, Ishikawa Y, Yamato M, et al. Spontaneous acquisition of infinite proliferative capacity by a rabbit corneal endothelial cell line with maintenance of phenotypic and physiological characteristics. J Tissue Eng Regen Med. 2017;11:1057-1064 pubmed publisher
  • immunocytochemistry; rat; 5 ng/ml
Arriagada A, Albornoz E, Opazo M, Becerra A, Vidal G, Fardella C, et al. Excess iodide induces an acute inhibition of the sodium/iodide symporter in thyroid male rat cells by increasing reactive oxygen species. Endocrinology. 2015;156:1540-51 pubmed publisher
  • immunohistochemistry; human
Kawano H, Sakamoto T, Ito T, Miyata K, Hashiguchi T, Maruyama I. Hyaluronan protection of corneal endothelial cells against extracellular histones after phacoemulsification. J Cataract Refract Surg. 2014;40:1885-93 pubmed publisher
  • western blot; rat
Ronzitti G, Bucci G, Emanuele M, Leo D, Sotnikova T, Mus L, et al. Exogenous ?-synuclein decreases raft partitioning of Cav2.2 channels inducing dopamine release. J Neurosci. 2014;34:10603-15 pubmed publisher
  • western blot; human
Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, et al. Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochem Biophys Res Commun. 2014;451:48-53 pubmed publisher
  • western blot; human
McEwen A, Maher M, Mo R, Gottardi C. E-cadherin phosphorylation occurs during its biosynthesis to promote its cell surface stability and adhesion. Mol Biol Cell. 2014;25:2365-74 pubmed publisher
  • western blot; mouse; fig 7a
Schneppenheim J, Hüttl S, Mentrup T, Lüllmann Rauch R, Rothaug M, Engelke M, et al. The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo. Mol Cell Biol. 2014;34:1398-411 pubmed publisher
  • immunocytochemistry; mouse
Yamazaki D, Funato Y, Miura J, Sato S, Toyosawa S, Furutani K, et al. Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model. PLoS Genet. 2013;9:e1003983 pubmed publisher
  • western blot; pigs
Yan Y, Shapiro A, Haller S, Katragadda V, Liu L, Tian J, et al. Involvement of reactive oxygen species in a feed-forward mechanism of Na/K-ATPase-mediated signaling transduction. J Biol Chem. 2013;288:34249-58 pubmed publisher
  • immunocytochemistry; human
Burgert T, Schmidt V, Caglayan S, Lin F, Füchtbauer A, Füchtbauer E, et al. SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013;33:4308-20 pubmed publisher
  • western blot; human; 1:1000
Kaphzan H, Buffington S, Ramaraj A, Lingrel J, Rasband M, Santini E, et al. Genetic reduction of the ?1 subunit of Na/K-ATPase corrects multiple hippocampal phenotypes in Angelman syndrome. Cell Rep. 2013;4:405-12 pubmed publisher
  • western blot; human; 1:10000; fig 4
Morita S, Tsuda T, Horikami M, Teraoka R, Kitagawa S, Terada T. Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes. J Lipid Res. 2013;54:1221-30 pubmed publisher
  • western blot; rat
Evans J, Rodriguez S, Ragolia L. ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling. Cell Tissue Res. 2013;352:413-25 pubmed publisher
Centrone M, De Santo M, Nicotera I, Labate C, Ranieri M, Di Mise A, et al. Gi Protein Modulation of the Potassium Channel TASK-2 Mediates Vesicle Osmotic Swelling to Facilitate the Fusion of Aquaporin-2 Water Channel Containing Vesicles. Cells. 2018;7: pubmed publisher
Smith M, Katsouri L, Virtue S, Choudhury A, Vidal Puig A, Ashford M, et al. Calcium Channel CaV2.3 Subunits Regulate Hepatic Glucose Production by Modulating Leptin-Induced Excitation of Arcuate Pro-opiomelanocortin Neurons. Cell Rep. 2018;25:278-287.e4 pubmed publisher
Banerjee M, Cui X, Li Z, Yu H, Cai L, Jia X, et al. Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. Sci Rep. 2018;8:12322 pubmed publisher
Dash B, Dib Hajj S, Waxman S. Multiple myosin motors interact with sodium/potassium-ATPase alpha 1 subunits. Mol Brain. 2018;11:45 pubmed publisher
Zoltowska K, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Sci Rep. 2018;8:8718 pubmed publisher
Nascimbeni A, Giordano F, Dupont N, Grasso D, Vaccaro M, Codogno P, et al. ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis. EMBO J. 2017;36:2018-2033 pubmed publisher
Rossi L, Nicoletti M, Carmosino M, Mastrofrancesco L, Di Franco A, Indrio F, et al. Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy. J Diabetes Res. 2017;2017:4360357 pubmed publisher
Dergousova E, Petrushanko I, Klimanova E, Mitkevich V, Ziganshin R, Lopina O, et al. Effect of Reduction of Redox Modifications of Cys-Residues in the Na,K-ATPase α1-Subunit on Its Activity. Biomolecules. 2017;7: pubmed publisher
Sun J, Hu F, Chen Y, Chu H, Chen W. Change of recipient corneal endothelial cells after non-descemet's stripping automated endothelial keratoplasty in a rabbit model. Invest Ophthalmol Vis Sci. 2014;55:8467-74 pubmed publisher
Lauf P, Alqahtani T, Flues K, Meller J, Adragna N. Interaction between Na-K-ATPase and Bcl-2 proteins BclXL and Bak. Am J Physiol Cell Physiol. 2015;308:C51-60 pubmed publisher
Resnier P, LeQuinio P, Lautram N, André E, Gaillard C, Bastiat G, et al. Efficient in vitro gene therapy with PEG siRNA lipid nanocapsules for passive targeting strategy in melanoma. Biotechnol J. 2014;9:1389-401 pubmed publisher
Skovgaard C, Christensen P, Larsen S, Andersen T, Thomassen M, Bangsbo J. Concurrent speed endurance and resistance training improves performance, running economy, and muscle NHE1 in moderately trained runners. J Appl Physiol (1985). 2014;117:1097-109 pubmed publisher
Xianyu M, Petrushanko I, Klimanova E, Dergousova E, Lopina O. Glutathionylation of the alpha-subunit of Na,K-ATPase from rat heart by oxidized glutathione inhibits the enzyme. Biochemistry (Mosc). 2014;79:158-64 pubmed publisher
Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed publisher
de Juan Sanz J, Núñez E, Villarejo López L, Pérez Hernández D, Rodriguez Fraticelli A, López Corcuera B, et al. Na+/K+-ATPase is a new interacting partner for the neuronal glycine transporter GlyT2 that downregulates its expression in vitro and in vivo. J Neurosci. 2013;33:14269-81 pubmed publisher
Barceló C, Paco N, Beckett A, Alvarez Moya B, Garrido E, Gelabert M, et al. Oncogenic K-ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status. J Cell Sci. 2013;126:4553-9 pubmed publisher
Fowler S, Akins M, Zhou H, Figeys D, Bennett S. The liver connexin32 interactome is a novel plasma membrane-mitochondrial signaling nexus. J Proteome Res. 2013;12:2597-610 pubmed publisher
Hirata Tominaga K, Nakamura T, Okumura N, Kawasaki S, Kay E, Barrandon Y, et al. Corneal endothelial cell fate is maintained by LGR5 through the regulation of hedgehog and Wnt pathway. Stem Cells. 2013;31:1396-407 pubmed publisher
Arakaki X, McCleary P, Techy M, Chiang J, Kuo L, Fonteh A, et al. Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat. Fluids Barriers CNS. 2013;10:14 pubmed publisher
Sumagin R, Robin A, Nusrat A, Parkos C. Activation of PKC?II by PMA facilitates enhanced epithelial wound repair through increased cell spreading and migration. PLoS ONE. 2013;8:e55775 pubmed publisher
Berret E, Nehme B, Henry M, Toth K, Drolet G, Mouginot D. Regulation of central Na+ detection requires the cooperative action of the NaX channel and ?1 Isoform of Na+/K+-ATPase in the Na+-sensor neuronal population. J Neurosci. 2013;33:3067-78 pubmed publisher
Costa T, Amer A, Farag S, Wolf Watz H, Fallman M, Fahlgren A, et al. Type III secretion translocon assemblies that attenuate Yersinia virulence. Cell Microbiol. 2013;15:1088-110 pubmed publisher
Bouyer P, Tang X, Weber C, Shen L, Turner J, Matthews J. Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1. Am J Physiol Gastrointest Liver Physiol. 2013;304:G142-56 pubmed publisher
Hatanaka H, Koizumi N, Okumura N, Takahashi H, Tanioka H, Young R, et al. A study of host corneal endothelial cells after non-Descemet stripping automated endothelial keratoplasty. Cornea. 2013;32:76-80 pubmed publisher
Mühlfeld S, Domanova O, Berlage T, Stross C, Helmer A, Keitel V, et al. Short-term feedback regulation of bile salt uptake by bile salts in rodent liver. Hepatology. 2012;56:2387-97 pubmed publisher
Petrushanko I, Yakushev S, Mitkevich V, Kamanina Y, Ziganshin R, Meng X, et al. S-glutathionylation of the Na,K-ATPase catalytic ? subunit is a determinant of the enzyme redox sensitivity. J Biol Chem. 2012;287:32195-205 pubmed publisher
Despa S, Lingrel J, Bers D. Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes. Cardiovasc Res. 2012;95:480-6 pubmed publisher
Tokhtaeva E, Clifford R, Kaplan J, Sachs G, Vagin O. Subunit isoform selectivity in assembly of Na,K-ATPase ?-? heterodimers. J Biol Chem. 2012;287:26115-25 pubmed publisher
Gunnarsson T, Bangsbo J. The 10-20-30 training concept improves performance and health profile in moderately trained runners. J Appl Physiol (1985). 2012;113:16-24 pubmed publisher
Evans J, Fernando A, Ragolia L. Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells. Mol Cell Endocrinol. 2012;355:60-70 pubmed publisher
Kaphzan H, Buffington S, Jung J, Rasband M, Klann E. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome. J Neurosci. 2011;31:17637-48 pubmed publisher
Peruchetti D, Pinheiro A, Landgraf S, Wengert M, Takiya C, Guggino W, et al. (Na+ + K+)-ATPase is a target for phosphoinositide 3-kinase/protein kinase B and protein kinase C pathways triggered by albumin. J Biol Chem. 2011;286:45041-7 pubmed publisher
Dunn D, He D, Yang P, Johansen M, Newman R, Lo D. In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. J Neurochem. 2011;119:805-14 pubmed publisher
Makihira S, Nikawa H, Kajiya M, Kawai T, Mine Y, Kosaka E, et al. Blocking of sodium and potassium ion-dependent adenosine triphosphatase-?1 with ouabain and vanadate suppresses cell-cell fusion during RANKL-mediated osteoclastogenesis. Eur J Pharmacol. 2011;670:409-18 pubmed publisher
Groen A, Romero M, Kunne C, Hoosdally S, Dixon P, Wooding C, et al. Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology. 2011;141:1927-37.e1-4 pubmed publisher
Banday A, Lokhandwala M. Angiotensin II-mediated biphasic regulation of proximal tubular Na+/H+ exchanger 3 is impaired during oxidative stress. Am J Physiol Renal Physiol. 2011;301:F364-70 pubmed publisher
Watanabe R, Hayashi R, Kimura Y, Tanaka Y, Kageyama T, Hara S, et al. A novel gelatin hydrogel carrier sheet for corneal endothelial transplantation. Tissue Eng Part A. 2011;17:2213-9 pubmed publisher
Basevich E, Lopina O, Rubtsov A. Seasonal changes in microsomal fraction enriched with Na,K-ATPase from kidneys of the ground squirrel Spermophilus undulatus. Biochemistry (Mosc). 2010;75:1408-16 pubmed
Yang Y, Dai M, Wilson T, Omelchenko I, Klimek J, Wilmarth P, et al. Na+/K+-ATPase α1 identified as an abundant protein in the blood-labyrinth barrier that plays an essential role in the barrier integrity. PLoS ONE. 2011;6:e16547 pubmed publisher
Gildea J, Kemp B, Howell N, Van Sciver R, Carey R, Felder R. Inhibition of renal caveolin-1 reduces natriuresis and produces hypertension in sodium-loaded rats. Am J Physiol Renal Physiol. 2011;300:F914-20 pubmed publisher
Proulx S, d Arc Uwamaliya J, Carrier P, Deschambeault A, Audet C, Giasson C, et al. Reconstruction of a human cornea by the self-assembly approach of tissue engineering using the three native cell types. Mol Vis. 2010;16:2192-201 pubmed
Dodrill M, Beezhold D, Meighan T, Kashon M, Fedan J. Lipopolysaccharide increases Na(+),K(+)-pump, but not ENaC, expression in guinea-pig airway epithelium. Eur J Pharmacol. 2011;651:176-86 pubmed publisher
Hisano Y, Kobayashi N, Kawahara A, Yamaguchi A, Nishi T. The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720. J Biol Chem. 2011;286:1758-66 pubmed publisher
Tokhtaeva E, Sachs G, Vagin O. Diverse pathways for maturation of the Na,K-ATPase ?1 and ?2 subunits in the endoplasmic reticulum of Madin-Darby canine kidney cells. J Biol Chem. 2010;285:39289-302 pubmed publisher
Chen X, Fahy A, Green A, Anderson M, Rhoads R, Limesand S. ?2-Adrenergic receptor desensitization in perirenal adipose tissue in fetuses and lambs with placental insufficiency-induced intrauterine growth restriction. J Physiol. 2010;588:3539-49 pubmed publisher
Törmäkangas L, Markkula E, Lounatmaa K, Puolakkainen M. Chlamydia pneumoniae infection in polarized epithelial cell lines. Infect Immun. 2010;78:2714-22 pubmed publisher
Thomassen M, Christensen P, Gunnarsson T, Nybo L, Bangsbo J. Effect of 2-wk intensified training and inactivity on muscle Na+-K+ pump expression, phospholemman (FXYD1) phosphorylation, and performance in soccer players. J Appl Physiol (1985). 2010;108:898-905 pubmed publisher
Illarionova N, Gunnarson E, Li Y, Brismar H, Bondar A, Zelenin S, et al. Functional and molecular interactions between aquaporins and Na,K-ATPase. Neuroscience. 2010;168:915-25 pubmed publisher
Mancuso J, Qian Y, Long C, Wu G, Wensel T. Distribution of RGS9-2 in neurons of the mouse striatum. J Neurochem. 2010;112:651-61 pubmed publisher
Kobayashi N, Kobayashi N, Yamaguchi A, Nishi T. Characterization of the ATP-dependent sphingosine 1-phosphate transporter in rat erythrocytes. J Biol Chem. 2009;284:21192-200 pubmed publisher
Egaña L, Cuevas R, Baust T, Parra L, Leak R, Hochendoner S, et al. Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3. J Neurosci. 2009;29:4592-604 pubmed publisher
Wang Y, Posner B, Balbis A. Compartmentalization of epidermal growth factor receptor in liver plasma membrane. J Cell Biochem. 2009;107:96-103 pubmed publisher
Proulx S, Bensaoula T, Nada O, Audet C, d Arc Uwamaliya J, Devaux A, et al. Transplantation of a tissue-engineered corneal endothelium reconstructed on a devitalized carrier in the feline model. Invest Ophthalmol Vis Sci. 2009;50:2686-94 pubmed publisher
Proulx S, Audet C, Uwamaliya J, Deschambeault A, Carrier P, Giasson C, et al. Tissue engineering of feline corneal endothelium using a devitalized human cornea as carrier. Tissue Eng Part A. 2009;15:1709-18 pubmed publisher
Hazelwood L, Free R, Cabrera D, Skinbjerg M, Sibley D. Reciprocal modulation of function between the D1 and D2 dopamine receptors and the Na+,K+-ATPase. J Biol Chem. 2008;283:36441-53 pubmed publisher
Ito D, Fujisawa T, Iida H, Suzuki N. Characterization of seipin/BSCL2, a protein associated with spastic paraplegia 17. Neurobiol Dis. 2008;31:266-77 pubmed publisher
Pastrana D, Yun C, McKee M, FitzGerald D. Mammalian cell expression of an active site mutant of Pseudomonas exotoxin disrupts LRP1 maturation. J Biomed Sci. 2008;15:427-39 pubmed publisher
Balbis A, Parmar A, Wang Y, Baquiran G, Posner B. Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes. Endocrinology. 2007;148:2944-54 pubmed
Okkenhaug H, Weylandt K, Carmena D, Wells D, Higgins C, Sardini A. The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus. FASEB J. 2006;20:2390-2 pubmed
Ohashi S, Mori A, Kurihara N, Mitsumoto Y, Nakai M. Age-related severity of dopaminergic neurodegeneration to MPTP neurotoxicity causes motor dysfunction in C57BL/6 mice. Neurosci Lett. 2006;401:183-7 pubmed
Doran P, Dowling P, Donoghue P, Buffini M, Ohlendieck K. Reduced expression of regucalcin in young and aged mdx diaphragm indicates abnormal cytosolic calcium handling in dystrophin-deficient muscle. Biochim Biophys Acta. 2006;1764:773-85 pubmed
Mori A, Ohashi S, Nakai M, Moriizumi T, Mitsumoto Y. Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice. Neurosci Res. 2005;51:265-74 pubmed
product information
Catalog Number :
05-369
Subcategory :
Neuroscience
Product Name :
Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P05023
Host Name :
Mouse
Antigen :
Na+/K+ ATPase α-1
Clone :
C464.6
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6
Cross Reactivity :
Human;Rat;Rabbit;Mouse;Monkey;Xenopus;Pig;Canine;Sheep
Background :
Na+/K+-ATPase (also known as the Na+/K+ pump or sodium-potassium pump) is an enzyme located in the plasma membrane (specifically an electrogenic transmembrane ATPase). It is found in the plasma membrane of virtually every human cell and is common to all cellular life. It helps maintain cell potential and regulate cellular volume. In order to maintain the cell potential, cells must keep a low concentration of sodium ions and high levels of potassium ions within the cell (intracellular). Outside cells (extracellular), there are high concentrations of sodium and low concentrations of potassium, so diffusion occurs through ion channels in the plasma membrane. In order to keep the appropriate concentrations, the sodium-potassium pump pumps sodium out and potassium in through active transport.
ALT Names :
ATPase, Na+/K+ transporting, alpha 3 polypeptide;Na(+)/K(+) ATPase alpha(III) subunit;Na(+)/K(+) ATPase alpha-3 subunit;Na+/K+ -ATPase alpha 3 subunit;Na+/K+ ATPase 3;Sodium pump subunit alpha-3;dystonia 12;sodium pump 3;sodium-potassium-ATPase, alpha 3 polypeptide;sodium/potassium-transporting ATPase alpha-3 chain
Immunogen :
Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla.
Specificity :
This antibody recognizes the α-1 subunit isoform of Na+/K+ ATPase.
Package Size :
50 µg
Uses :
Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Western Blotting
Storage :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.