Clusterin α chain (human) Antibody, clone 41D | EMD Millipore 05-354 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Clusterin α chain (human) Antibody, clone 41D

catalog :

05-354

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

41D

The same clone is also sold as:

LifeSpan Biosciences: LS-C84907

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 2c	Bonacini M, Negri A, Davalli P, Naponelli V, Ramazzina I, Lenzi C, et al. Clusterin Silencing in Prostate Cancer Induces Matrix Metalloproteinases by an NF-κB-Dependent Mechanism. J Oncol. 2019;2019:4081624 pubmed publisher
western blot; human; loading ...	Jongbloed W, Herrebout M, Blankenstein M, Veerhuis R. Quantification of clusterin in paired cerebrospinal fluid and plasma samples. Ann Clin Biochem. 2014;51:557-67 pubmed publisher
	Chesnokov V, Gong B, Sun C, Itakura K. Anti-cancer activity of glucosamine through inhibition of N-linked glycosylation. Cancer Cell Int. 2014;14:45 pubmed publisher
	Chayka O, Corvetta D, Dews M, Caccamo A, Piotrowska I, Santilli G, et al. Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas. J Natl Cancer Inst. 2009;101:663-77 pubmed publisher
	Nilselid A, Davidsson P, Nagga K, Andreasen N, Fredman P, Blennow K. Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochem Int. 2006;48:718-28 pubmed

product information

Catalog Number :

05-354

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Clusterin α chain (human) Antibody, clone 41D

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10909

Host Name :

Mouse

Antigen :

Clusterin α chain (human)

Clone :

41D

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Clusterin α chain (human) Antibody, clone 41D

Cross Reactivity :

Human

Background :

Clusterin is also known as apolipoprotein J, complement lysis inhibitor, gp80, glycoprotein III, SGP-2, SP 40-40, TRPM2 and T64. It is a ubiquitous multifunctional protein of 80kD comprising of two disulfide-linked subunits, alpha and beta, and capable of interacting with a broad range of molecules. It is implicated in numerous biological processes including sperm maturation, lipid transport, regulation of the complement cascade, membrane recycling, cell death, immune regulation, cell adhesion and morphological transformation. In pathological conditions, it is an amyloid associated protein co-localising with fibrillar deposits in systemic and localised amyloid disorders. In Alzheimer ’s disease, clusterin is present in amyloid plaques and cerebrovascular deposits. In breast cancers, clusterin expression was found to correlate with tumour size. Clusterin is also implicated with endometrial cancers, myocardial infarction, renal diseases and atherosclerosis.

ALT Names :

Apolipoprotein J;Complement cytolysis inhibitor;Complement-associated protein SP-40,40;Ku70-binding protein 1;Testosterone-repressed prostate message 2;aging-associated protein 4;clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J);complement lysis inhibitor;complement-associated protein SP-40;sulfated glycoprotein 2

Immunogen :

Native clusterin purified from human serum. Clone 41D.

Specificity :

This antibody recognizes human clusterin α chain, Mr 40 kDa, and precursor protein.

Package Size :

100 µg

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.