PI3 Kinase Antibody, p85, N-SH2, | EMD Millipore 05-217 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PI3 Kinase Antibody, p85, N-SH2,

catalog :

05-217

quantity :

200 µL

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

UB93-3

reactivity :

African green monkey, human, mouse

application :

western blot, immunoprecipitation

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; African green monkey; loading ...; fig 1c	Whitecross D, Anderson D. Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase. Sci Rep. 2017;7:16194 pubmed publisher
western blot; human; tbl s3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
	Zhao Y, Biswas S, McNulty P, Kozak M, Jun J, Segar L. PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Am J Physiol Cell Physiol. 2011;300:C1375-85 pubmed publisher
	Chamberlain M, Oberg J, Furber L, Poland S, Hawrysh A, Knafelc S, et al. Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking. Cell Signal. 2010;22:1562-75 pubmed publisher
	Zhou L, Takayama Y, Boucher P, Tallquist M, Herz J. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS ONE. 2009;4:e6922 pubmed publisher
	Biswas S, Zhao Y, Sandirasegarane L. Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells. Mol Vis. 2009;15:1599-610 pubmed
	Biswas S, Zhao Y, Nagalingam A, Gardner T, Sandirasegarane L. PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells. Invest Ophthalmol Vis Sci. 2008;49:3687-98 pubmed publisher
	Rombouts K, Lottini B, Caligiuri A, Liotta F, Mello T, Carloni V, et al. MARCKS is a downstream effector in platelet-derived growth factor-induced cell motility in activated human hepatic stellate cells. Exp Cell Res. 2008;314:1444-54 pubmed publisher

product information

Catalog Number :

05-217

Subcategory :

Cell Signaling

Product Name :

Anti-PI3 Kinase Antibody, p85, N-SH2,

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P27986

Host Name :

Mouse

Antigen :

PI3 Kinase

Clone :

clone UB93-3

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-PI3 Kinase Antibody, p85, N-SH2,

Cross Reactivity :

Human;Mouse;Rat

Background :

The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that is thought to phosphorylate second messengers in growth signalling pathways. PI3K exists as a heterodimer of catalytic 110 kDa (p110) and regulatory 85 kDa (p85, p50 or p55) subunits. The p85 unit consists of two closely related proteins: p85 alpha, which binds tightly to the catalytic subunit and p85 beta, a protein of unknown function. They share 62% amino acid sequence identity. p85 alpha lacks PI3 kinase activity, but may serve as regulator of the catalytic subunit, p110, by acting as the link between PI3K and the ligand activated receptor. Both isoforms bind to activated receptors and serve as tyrosine kinase substrates.

ALT Names :

PI3-kinase p110 subunit alpha;PtdIns-3-kinase p110;phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha;phosphatidylinositol 3-kinase, catalytic, alpha polypeptide;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic;subunit, alpha isoform;phosphoinositide-3-kinase, catalytic, alpha polypeptide

Immunogen :

GST fusion protein corresponding to N-Terminal SH2 region (amino acid residues 327-434) of rat phosphoinositide 3-Kinase.

Specificity :

Recognizes N-SH2 region of p85 alpha subunit of PI3 Kinase.

Package Size :

200 µL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at from date of receipt.