G3BP1 Antibody, clone 14E5-G9 | EMD Millipore 05-1938 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

G3BP1 Antibody, clone 14E5-G9

catalog :

05-1938

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14E5-G9

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; fig 3f	Markmiller S, Soltanieh S, Server K, Mak R, Jin W, Fang M, et al. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018;172:590-604.e13 pubmed publisher
immunoprecipitation; human; fig 2	Gal J, Kuang L, Barnett K, Zhu B, Shissler S, Korotkov K, et al. ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol. 2016;132:563-76 pubmed publisher
immunocytochemistry; human; 1:1000; loading ...; fig s4	Hu S, Li J, Xu F, Mei S, Le Duff Y, Yin L, et al. SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation. PLoS Genet. 2015;11:e1005367 pubmed publisher
	Janzer A, Lim S, Fronhoffs F, Niazy N, Buettner R, Kirfel J. Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components. Biochem Biophys Res Commun. 2012;421:665-70 pubmed publisher

product information

Catalog Number :

05-1938

Subcategory :

Cell Signaling

Product Name :

Anti-G3BP1 Antibody, clone 14E5-G9

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13283

Host Name :

Mouse

Antigen :

G3BP1

Clone :

14E5-G9

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-G3BP1 Antibody, clone 14E5-G9

Cross Reactivity :

Human

Background :

G3BP1 (Ras-GTPase activating protein SH3-domain binding protein 1) directly associates with SH3 domains of GTPase activating proteins (GAPs). It was first discovered by its binding to RasGAP. G3BPs have been shown to be involved in a number of mitogenic signaling pathways. G3BP1 is also known to be over expressed in many human cancers (Kim, 2007) and its expression appears to be inversely correlated with PTEN expression (Kim, 2007). Interestingly, G3BP1, along with G3BP2, has been shown to bind to the C-terminus of p53, playing a crucial role in its activity (Kim, 2007). Furthermore, the G3BPs have two traditional RNA binding motifs.

ALT Names :

ATP-dependent DNA helicase VIII;GAP SH3 domain-binding protein 1;GAP binding protein;GTPase activating protein (SH3 domain) binding protein 1;Ras-GTPase-activating protein SH3-domain-binding protein;RasGAP-associated endoribonuclease G3BP

Immunogen :

GST-tagged recombinant protein corresponding to human G3BP1.

Specificity :

This antibody recognizes G3BP1.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt