IGF-I Antibody, clone Sm1.2 | EMD Millipore 05-172 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-I Antibody, clone Sm1.2

catalog :

05-172

quantity :

200 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Sm1.2

The same clone is also sold as:

LifeSpan Biosciences: LS-C85204

reactivity :

human, mouse, chicken

application :

western blot, immunohistochemistry, neutralization, immunoprecipitation

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:500; loading ...; fig 5d	Parvaneh Tafreshi A, Talebi F, Ghorbani S, Bernard C, Noorbakhsh F. Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis. J Comp Neurol. 2017;525:3072-3082 pubmed publisher
immunohistochemistry; mouse; loading ...; fig s7a	Xie X, Tsai S, Tsai M. COUP-TFII regulates satellite cell function and muscular dystrophy. J Clin Invest. 2016;126:3929-3941 pubmed publisher
western blot; human; fig 6	Vishwamitra D, Curry C, Alkan S, Song Y, Gallick G, Kaseb A, et al. The transcription factors Ik-1 and MZF1 downregulate IGF-IR expression in NPM-ALKâº T-cell lymphoma. Mol Cancer. 2015;14:53 pubmed publisher
western blot; mouse	Lu R, Wang Q, Han Y, Li J, Yang X, Miao D. Parathyroid hormone administration improves bone marrow microenvironment and partially rescues haematopoietic defects in Bmi1-null mice. PLoS ONE. 2014;9:e93864 pubmed publisher
western blot; human	Jacobo S, DeAngelis M, Kim I, Kazlauskas A. Age-related macular degeneration-associated silent polymorphisms in HtrA1 impair its ability to antagonize insulin-like growth factor 1. Mol Cell Biol. 2013;33:1976-90 pubmed publisher
	Li W, Guan T, Zhang X, Wang Z, Wang M, Zhong W, et al. The Effect of Layer-by-Layer Assembly Coating on the Proliferation and Differentiation of Neural Stem Cells. ACS Appl Mater Interfaces. 2015;7:3018-29 pubmed publisher
	Chiu I, Chen A, Zheng Y, Kosaras B, Tsiftsoglou S, Vartanian T, et al. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008;105:17913-8 pubmed publisher
	Shimizu M, Deguchi A, Hara Y, Moriwaki H, Weinstein I. EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. Biochem Biophys Res Commun. 2005;334:947-53 pubmed

product information

Catalog Number :

05-172

Subcategory :

Cell Signaling

Product Name :

Anti-IGF-I Antibody, clone Sm1.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P05019

Host Name :

Mouse

Antigen :

IGF-I

Clone :

Sm1.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IGF-I Antibody, clone Sm1.2

Cross Reactivity :

Human;Mouse;Rat;Chicken;Avian

Background :

Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 is produced primarily by the liver as an endocrine hormone and targets tissues in a paracrine/autocrine fashion. Production is stimulated by growth hormone and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5b. Approximately 98% of IGF-1 is always bound to one of 6 binding proteins (IGF-BP). IGFBP-3, the most abundant protein, accounts for 80% of all IGF binding. IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. Its primary action is mediated by binding to specific IGF receptors present on many cell types in many tissues. The signal is transduced by intracellular events. IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and multiplication and a potent inhibitor of programmed cell death.

ALT Names :

Mechano growth factor;insulin-like growth factor 1;insulin-like growth factor 1 (somatomedin C);somatomedin C

Immunogen :

Human insulin-like growth factor I (IGF-I) purified from human plasma. (van Wyk, J.J., 1986).

Specificity :

IGF-I. (Russel, W.E., 1984). 40% cross reactivity to IGF-II. (van Wyk, J.J., 1997).

Package Size :

200 μg

Uses :

Immunohistochemistry;Immunoprecipitation;Neutralizing;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.