PLCγ-1 Antibody | EMD Millipore 05-163 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PLCγ-1 Antibody

catalog :

05-163

quantity :

50 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 6

Reference
Anderson E, Wissman A, Chemplanikal J, BUZIN N, Guzman D, Larson E, et al. BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors. Proc Natl Acad Sci U S A. 2017;114:9469-9474 pubmed publisher
Kongsbak M, von Essen M, Levring T, Schjerling P, Woetmann A, Ã˜dum N, et al. Vitamin D-binding protein controls T cell responses to vitamin D. BMC Immunol. 2014;15:35 pubmed publisher
Tan Y, Manz B, Freedman T, Zhang C, Shokat K, Weiss A. Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nat Immunol. 2014;15:186-94 pubmed publisher
Matsumoto K, Shimizu N. Activation of the phospholipase C signaling pathway in nerve growth factor-treated neurons by carbon nanotubes. Biomaterials. 2013;34:5988-94 pubmed publisher
Chen D, Bambah Mukku D, Pollonini G, Alberini C. Glucocorticoid receptors recruit the CaMKII?-BDNF-CREB pathways to mediate memory consolidation. Nat Neurosci. 2012;15:1707-14 pubmed publisher
Kwon Y, Jang H, Kole S, He H, Bernier M. Role of the pleckstrin homology domain of PLCgamma1 in its interaction with the insulin receptor. J Cell Biol. 2003;163:375-84 pubmed

product information

Catalog Number :

05-163

Subcategory :

Cell Signaling

Product Name :

Anti-PLCγ-1 Antibody

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P19174

Host Name :

Mouse

Antigen :

PLCγ-1

Clone :

Clonal blend B-2-5, B-6-4, B-20-3, D-7-3, E-9-4.

Conjugate :

Purified

Isotype :

mixed IgGs

Product Description :

Anti-PLCγ-1 Antibody

Cross Reactivity :

Human;Mouse;Rat;Rabbit;Bovine

Background :

Phospholipase C gamma 1 is a tyrosine kinase substrate for many receptor and nonreceptor tyrosine kinases. Activation of the enzyme produces two second messenger molecules, inositol 1,4,5-trisphosphate and diacylglycerol, which provoke the mobilization of intracellular Ca2+ and activation of protein kinase C. Although the mammalian genome encodes 10 known phosphoinositide specific PLCs, only the gamma 1 and gamma 2 isoforms are regulated by tyrosine kinase activity. PLC beta isoform activity is controlled by heterotrimeric G protein coupled receptors, while the mechanism of regulation of PLCgamma activity is unknown.

ALT Names :

1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1;Phosphoinositide phospholipase C;Phospholipase C-gamma-1;monophosphatidylinositol phosphodiesterase;phosphatidylinositol phospholipase C;phosphoinositidase C;phospholipase C gamma 1;phospholipase C, gamma 1;phospholipase C, gamma 1 (formerly subtype 148);phospholipase C-148;triphosphoinositide phosphodiesterase

Immunogen :

Five individual clones raised against purified soluble phospholipase C (PLC)γ-1 from bovine brain.

Specificity :

This antibody recognizes PLCγ-1, Mr 135 kDa. Reacts with some non-PLCγ-1 SH-3 containing proteins, including nck, Mr 47kDa (Park, D., 1992).

Package Size :

50 µg

Uses :

Immunocytochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of shipment.