mTOR Antibody, clone 2ID8.2 | EMD Millipore 05-1592 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

mTOR Antibody, clone 2ID8.2

catalog :

05-1592

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2ID8.2

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; loading ...; fig 1i	Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher

product information

Catalog Number :

05-1592

Subcategory :

Cell Signaling

Product Name :

Anti-mTOR Antibody, clone 2ID8.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42345

Host Name :

Mouse

Antigen :

mTOR

Clone :

2ID8.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-mTOR Antibody, clone 2ID8.2

Cross Reactivity :

Human;Mouse

Background :

mTOR (Mammalian Target of Rapamycin, aka FRAP, RAPT or RAFT) is a large 289 kDa Ser/Thr protein kinase that regulates cell cycle progression, cell growth, protein synthesis, ribosome biogenesis, and autophagy. mTOR is an evolutionarily conserved member of the Phosphoinositol Kinase-related Kinase (PIKK) family whose activity is regulated by phosphorylation on Ser2448 by Akt in response to insulin or muscle activity. mTORC1 (mTOR Complex 1) consists of at least mTOR, Raptor, and G (mLST8). mTORC1 is known to play a central role in insulin signaling, which is crucial in maintaining metabolic homeostasis. mTORC2 affects cell proliferation and survival primarily by phosphorylating the hydrophobic motif of Akt on Ser473, a well-known effecter of the PI3 Kinase pathway. In addition to phosphorylating Akt, the mTORC2 complex is also known to effect cytoskeletal organization and migration by exerting its effects through Rac, Rho, and PKC. Defects in both mTOR complexes are associated with a variety of diseases, including cancer and diabetes.

ALT Names :

FK506 binding protein 12-rapamycin associated protein 1;FK506 binding protein 12-rapamycin associated protein 2;FK506-binding protein 12-rapamycin complex-associated protein 1;FKBP-rapamycin associated protein ;FKBP12-rapamycin complex-associated protein 1;Mammalian target of rapamycin ;Rapamycin target protein ;mechanistic target of rapamycin (serine/threonine kinase);rapamycin and FKBP12 target 1;rapamycin associated protein FRAP2

Immunogen :

Flag-tagged recombinant protein corresponding to residues surrounding mTOR.

Specificity :

This antibody recognizes mTOR.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Maintain refrigerated at 2-8°C for 1 year from date of receipt.