U1-70K Antibody, clone 9C4.1 | EMD Millipore 05-1588 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

U1-70K Antibody, clone 9C4.1

catalog :

05-1588

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

9C4.1

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:2000; loading ...; fig 2A western blot; human; loading ...; fig 1A	Yu Y, Chi B, Xia W, Gangopadhyay J, Yamazaki T, Winkelbauer Hurt M, et al. U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish. Nucleic Acids Res. 2015;43:3208-18 pubmed publisher
	Subramania S, Gagné L, Campagne S, Fort V, O Sullivan J, Mocaer K, et al. SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing. Nucleic Acids Res. 2019;47:4181-4197 pubmed publisher
	Bishof I, Dammer E, Duong D, Kundinger S, Gearing M, Lah J, et al. RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease. J Biol Chem. 2018;293:11047-11066 pubmed publisher

product information

Catalog Number :

05-1588

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-U1-70K Antibody, clone 9C4.1

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08621

Host Name :

Mouse

Antigen :

U1-70K

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-U1-70K Antibody, clone 9C4.1

Cross Reactivity :

Human;Mouse;Rat

Background :

U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) is one of three specific proteins found within the U1 snRNP core, which includes at least seven core proteins found in all U snRNPs and three specific proteins; U1-70K, U1-A, and U1-C. U1-70K is involved in mediating pre-mRNA splicing through binding the loop I region of U1-snRNA with its RPM (RNA recognition motif) binding domain. In addition, its RNA binding domain, U1-70K also contains two argine-rich regions, accented with acidic or serine residues, that is thought to have trans-acting functions. Alternative splicing results in 4 known isoforms. Truncated forms of U1-70K are unable to bind RNA.

ALT Names :

small nuclear ribonucleoprotein 70kDa (U1);U1 small nuclear ribonucleoprotein 70 kDa;small nuclear ribonucleoprotein 70kDa (RNP antigen);U1 snRNP 70 kDa

Immunogen :

Recombinant protein corresponding to C-terminal domain of human U1-70K.

Specificity :

This antibody recognizes U1-70K at the C-terminal domain.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt