This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
MDC1 Antibody, clone P2B11
catalog :
05-1572
quantity :
100 μg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human, mouse, bovine, chimpanzee
application :
western blot, immunocytochemistry, western blot knockout validation
citations: 6
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 1g
  • immunocytochemistry; human; 1:1000; loading ...; fig 1f
Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, et al. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nat Commun. 2018;9:2736 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 2d
Gong Y, Handa N, Kowalczykowski S, de Lange T. PHF11 promotes DSB resection, ATR signaling, and HR. Genes Dev. 2017;31:46-58 pubmed publisher
  • immunocytochemistry; human; 1:500; fig s1
Mackay D, Ullman K. ATR and a Chk1-Aurora B pathway coordinate postmitotic genome surveillance with cytokinetic abscission. Mol Biol Cell. 2015;26:2217-26 pubmed publisher
Peng Y, Liao Q, Tan W, Peng C, Hu Z, Chen Y, et al. The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors. Nat Commun. 2019;10:1224 pubmed publisher
Li Y, Luo K, Yin Y, Wu C, Deng M, Li L, et al. USP13 regulates the RAP80-BRCA1 complex dependent DNA damage response. Nat Commun. 2017;8:15752 pubmed publisher
Mayer A, Baran V, Sakakibara Y, Brzakova A, Ferencova I, Motlik J, et al. DNA damage response during mouse oocyte maturation. Cell Cycle. 2016;15:546-58 pubmed publisher
product information
Catalog Number :
05-1572
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-MDC1 Antibody, clone P2B11
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
Q5PSV9
Host Name :
Mouse
Antigen :
MDC1
Clone :
P2B11
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-MDC1 Antibody, clone P2B11
Cross Reactivity :
Mouse;Human;Chimpanzee;Bovine
Background :
MDC1 is a subunit of the cohesin complex and is an essential protein required for sister chromatid cohesion in mitosis and meiosis. Temperature-sensitive mutations of this protein have been associated with defects in sister chromatid cohesion, chromosome condensation, and chromosome segregation. Its expression is cell cycle regulated and peaks in S phase. Expression of MDC1 is required for the S- and G2/M-checkpoint-mediated cell cycle arrest in response to DNA damage. MDC1 has been shown to interact with H2A.X near sites of DNA double-strand breaks and recruit ATM kinase to the damaged region of DNA. Consistent with this role, MDC1 also appears to modulate the function of other proteins involved in the DNA damage checkpoint such as BRCA1 and Chk2.
ALT Names :
Nuclear factor with BRCT domains 1;homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint 1
Immunogen :
GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus.
Specificity :
This antibody recognizes MDC1 at and around the N-terminus.
Package Size :
100 μg
Uses :
Immunocytochemistry;Western Blotting
Storage :
Stable for 1 year at 2-8°C from date of receipt
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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