IGF-1R Antibody, clone 24-57 | EMD Millipore 05-1571 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-1R Antibody, clone 24-57

catalog :

05-1571

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24-57

The same clone is also sold as:

Invitrogen: MA5-13812
LifeSpan Biosciences: LS-C88323

reactivity :

human

application :

immunohistochemistry, immunoprecipitation

citations: 1

Reference
Chang C, Wang Y, Trisal P, Li R, Rossi D, Nair A, et al. Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines. PLoS ONE. 2012;7:e44235 pubmed publisher

product information

Catalog Number :

05-1571

Subcategory :

Metabolism

Product Name :

Anti-IGF-1R Antibody, clone 24-57

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08069

Host Name :

Mouse

Antigen :

IGF-1R

Clone :

24-57

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-IGF-1R Antibody, clone 24-57

Cross Reactivity :

Human

Background :

There are two kinds of IGF receptors based on their relative affinities for IGF1 versus IGF2. The IGF1 receptor prefers IGF1 over IGF2 and weakly binds insulin. IGF1 receptor is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha (130 kDa) and two beta (95 kDa) subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The IGF1 receptor is therefore similar in structure to the insulin receptor. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The IGF1 receptor is highly expressed in all cell types and tissues and is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.

ALT Names :

CD221 antigen;IGF-I receptor;Insulin-like growth factor I receptor;insulin-like growth factor 1 receptor;soluble IGF1R variant 1;soluble IGF1R variant 2

Immunogen :

KLH-conjugated linear peptide corresponding to human IGF-IR.

Specificity :

This antibody recognizes IGF-IR.

Package Size :

100 μg

Uses :

Immunohistochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt