Importin beta-1 Antibody, clone 3H14 | EMD Millipore 05-1530 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Importin beta-1 Antibody, clone 3H14

catalog :

05-1530

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3H14

reactivity :

human

application :

western blot, immunocytochemistry

citations: 1

Reference
Mariani L, Monfulleda N, Alemany L, Vizza E, Marandino F, Vocaturo A, et al. Human papillomavirus prevalence and type-specific relative contribution in invasive cervical cancer specimens from Italy. BMC Cancer. 2010;10:259 pubmed publisher

product information

Catalog Number :

05-1530

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Importin beta-1 Antibody, clone 3H14

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q14974

Host Name :

Mouse

Antigen :

Importin beta-1

Clone :

3H14

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Importin beta-1 Antibody, clone 3H14

Cross Reactivity :

Human

Background :

Importin beta-1 (also known as Importin subunit beta-1) facilitates nuclear protein import. This occurs either though association with a nuclear localization signal (NLS) and an adapter protein , such as an importin-alpha subunit, which which binds to nuclear, or directly where the protein acts as autonomous nuclear transport receptor. Import of macromolecules containing a NLS requires a heterodimer of importin alpha and beta subunits also called as karyopherins. Importin alpha binds the cytoplasmic NLS-containing protein and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. Movement through the nuclear pore is mediated by the small GTP binding protein Ran via an energy requiring mechanism. Using nucleotide triphosphates and Ran, the nuclear transport complex moves into the nuclear pore and the importin subunits dissociate. Importin alpha and its passenger protein enter the nucleoplasm while importin beta remains at the pore.

ALT Names :

Karyopherin subunit beta-1;Nuclear factor P97;importin 1;importin 90;importin beta-1 subunit;karyopherin (importin) beta 1;karyopherin beta 1

Immunogen :

Recombinant protein corresponding to human Importin beta-1.

Specificity :

This antibody recognizes Importin beta-1.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt