hnRNP A2/B1 Antibody, clone DP383 | EMD Millipore 05-1522 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

hnRNP A2/B1 Antibody, clone DP383

catalog :

05-1522

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DP383

reactivity :

human

application :

western blot, immunohistochemistry, immunoprecipitation

product information

Catalog Number :

05-1522

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-hnRNP A2/B1 Antibody, clone DP383

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P22626

Host Name :

Mouse

Antigen :

hnRNP A2/B1

Clone :

DP383

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-hnRNP A2/B1 Antibody, clone DP383

Cross Reactivity :

Human

Background :

The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and associate with pre-mRNAs in the nucleus. These complexes are associated with pre-mRNA processing and other aspects of mRNA metabolism and transport. While all hnRNPs are present in the nucleus, data suggests they shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by hnRNP A2/B1 belongs to the A/B subfamily of ubiquitously express hnRNPs. This family member has two repeats of quasi-RRM domains that bind to RNAs. Two alternatively spliced transcript variants which encode different isoforms have been described. In autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, and mixed connective tissue disease hnRNPA2B1 can serve as an autoantigen. Although this protein is predominantly nucleoplasmic, in some tissues isoform A2 is found in the cytoplasm.

ALT Names :

heterogeneous nuclear ribonucleoprotein A2/B1;heterogeneous nuclear ribonucleoprotein B1;hnRNP A2 / hnRNP B1;nuclear ribonucleoprotein particle A2 protein

Immunogen :

Recombinant protein corresponding to human hnRNP A2/B1.

Specificity :

This antibody recognizes hnRNP A2/B1.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt