hnRNP A1 Antibody, clone 4B10 | EMD Millipore 05-1521 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

hnRNP A1 Antibody, clone 4B10

catalog :

05-1521

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4B10

The same clone is also sold as:

Abnova: MAB2483
Invitrogen: MA5-24774
LifeSpan Biosciences: LS-C82261
Santa Cruz Biotechnology: sc-32301
MilliporeSigma: R9778
Novus Biologicals: NB100-672, NBP2-80776
ImmuQuest: IQ262, IQ205

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 4a	Libner C, Salapa H, Hutchinson C, Lee S, Levin M. Antibodies to the RNA binding protein heterogeneous nuclear ribonucleoprotein A1 contribute to neuronal cell loss in an animal model of multiple sclerosis. J Comp Neurol. 2020;528:1704-1724 pubmed publisher
	Collier S, Henderson M, Tossberg J, Aune T. Regulation of the Th1 genomic locus from Ifng through Tmevpg1 by T-bet. J Immunol. 2014;193:3959-65 pubmed publisher
	Pham D, Vincentz J, Firulli A, Kaplan M. Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol. 2012;189:832-40 pubmed publisher
	Ziaei S, Shimada N, Kucharavy H, Hubbard K. MNK1 expression increases during cellular senescence and modulates the subcellular localization of hnRNP A1. Exp Cell Res. 2012;318:500-8 pubmed publisher

product information

Catalog Number :

05-1521

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-hnRNP A1 Antibody, clone 4B10

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09651

Host Name :

Mouse

Antigen :

hnRNP A1

Clone :

4B10

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-hnRNP A1 Antibody, clone 4B10

Cross Reactivity :

Human

Background :

The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and associate with pre-mRNAs in the nucleus. These complexes are associated with pre-mRNA processing and other aspects of mRNA metabolism and transport. While all hnRNPs are present in the nucleus, data suggests they shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by hnRNP A1 has two repeats of quasi-RRM domains that bind to RNAs. This abundant core protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. The hnRNP A1 protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may have a role in splice site selection.

ALT Names :

Helix-destabilizing protein;Single-strand RNA-binding protein;heterogeneous nuclear ribonucleoprotein A1;heterogeneous nuclear ribonucleoprotein A1B protein;heterogeneous nuclear ribonucleoprotein B2 protein;heterogeneous nuclear ribonucleoprotein core protein A1;hnRNP core protein A1;nuclear ribonucleoprotein particle A1 protein;single-strand DNA-binding protein UP1

Immunogen :

Full length native protein partially purified human hnRNP A1.

Specificity :

This antibody recognizes hnRNP A1.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt