Raptor Antibody, clone 1H6.2 | EMD Millipore 05-1470 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Raptor Antibody, clone 1H6.2

catalog :

05-1470

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H6.2

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, proximity ligation assay

citations: 9

Published Application/Species/Sample/Dilution	Reference
proximity ligation assay; human; loading ...; fig 3d immunoprecipitation; human; loading ...; fig 1h	Su K, Cao J, Tang Z, Dai S, He Y, Sampson S, et al. HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Nat Cell Biol. 2016;18:527-39 pubmed publisher
western blot; human; loading ...; fig 4j	Komatsu N, Fujita Y, Matsuda M, Aoki K. mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells. Oncogene. 2015;34:5607-16 pubmed publisher
immunoprecipitation; human	Lu J, Zavorotinskaya T, Dai Y, Niu X, Castillo J, Sim J, et al. Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation. Blood. 2013;122:1610-20 pubmed publisher
western blot; human; 1:500	McNulty S, Flint M, Nichol S, Spiropoulou C. Host mTORC1 signaling regulates andes virus replication. J Virol. 2013;87:912-22 pubmed publisher
	Dhar S, Bakthavatchalu V, Dhar B, Chen J, Tadahide I, Zhu H, et al. DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling. Oncogene. 2018;37:6225-6242 pubmed publisher
	Ying Z, Jin M, Peterson L, Bernard D, Saiya Cork K, Yildiz M, et al. Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma. Clin Cancer Res. 2016;22:5383-5393 pubmed
	Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher
	Hong S, Mannan A, Inoki K. Evaluation of the nutrient-sensing mTOR pathway. Methods Mol Biol. 2012;821:29-44 pubmed publisher
	Aslan J, Tormoen G, Loren C, Pang J, McCarty O. S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation. Blood. 2011;118:3129-36 pubmed publisher

product information

Catalog Number :

05-1470

Subcategory :

Cell Signaling

Product Name :

Anti-Raptor Antibody, clone 1H6.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q8N122

Host Name :

Mouse

Antigen :

Raptor

Clone :

1H6.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Raptor Antibody, clone 1H6.2

Cross Reactivity :

Human;Mouse

Background :

Raptor is a subunit of mTORC1 which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Within mTORC1, Raptor positively regulates mTORC1 activity and functions as a scaffold for recruiting mTORC1 substrates.

ALT Names :

P150 target of rapamycin (TOR)-scaffold protein;p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats;regulatory associated protein of mTOR

Immunogen :

Recombinant protein corresponding to human Raptor.

Specificity :

This antibody recognizes Raptor.

Package Size :

100 μg

Uses :

Western Blotting;Immunoprecipitation;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt