Phospholipase A2 Antibody, clone CH-7 | EMD Millipore 05-1406 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Phospholipase A2 Antibody, clone CH-7

catalog :

05-1406

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CH-7

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
ELISA; human	Osborne C, West E, Nolan W, McHale Owen H, Williams A, Bate C. Glimepiride protects neurons against amyloid-Î²-induced synapse damage. Neuropharmacology. 2016;101:225-36 pubmed publisher
ELISA; mouse; 0.5 ug/ml	Bate C, Williams A. cAMP-Inhibits Cytoplasmic Phospholipase Aâ‚‚ and Protects Neurons against Amyloid-Î²-Induced Synapse Damage. Biology (Basel). 2015;4:591-606 pubmed publisher
ELISA; human	Williams R, Bate C. An in vitro model for synaptic loss in neurodegenerative diseases suggests a neuroprotective role for valproic acid via inhibition of cPLA2 dependent signalling. Neuropharmacology. 2016;101:566-75 pubmed publisher
ELISA; mouse; fig 2a	Bate C, Williams A. Î±-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2. Biomolecules. 2015;5:178-93 pubmed publisher
	Bate C, Williams A. Neurodegeneration induced by clustering of sialylated glycosylphosphatidylinositols of prion proteins. J Biol Chem. 2012;287:7935-44 pubmed publisher

product information

Catalog Number :

05-1406

Subcategory :

Cell Signaling

Product Name :

Anti-Phospholipase A2 Antibody, clone CH-7

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P04054

Host Name :

Mouse

Antigen :

Phospholipase A2

Clone :

CH-7

Conjugate :

Purified

Isotype :

IgG2b

Product Description :

Anti-Phospholipase A2 Antibody, clone CH-7

Cross Reactivity :

Human;Mouse;Rat

Background :

Phospholipases hydrolyze phosphoglycerides to form smaller compounds which often serve as critical second messengers. Phospholipase A2 (PLA2) hydrolyzes phosphatidylcholine to produce lysophosphatidylcholine, a second messenger involved in cell proliferation, adhesion, T-cell activation, and smooth muscle cell contractility. PLA2 isoforms include membrane-associated, Ca2+-independent forms, cytosolic, Ca2+-dependent forms, and secretory forms. PLC catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, to generate inositol (1,4,5) trisphosphate (IP3) and diacylglycerol (DAG), leading to Ca2+ release and PKC activation, respectively. At least four types of PLC have been identified. PLCβ, is activated by G-Protein-Coupled Receptors (GPCRs) and heterotrimeric G-Proteins. Mechanisms of PLCδ activation are unclear, but may also involve GPCRs. PLCγ, is activated by receptor tyrosine kinases, and appears essential for signaling by the PDGF Receptor. PLCε is a Guanine Nucleotide Exchange factor (GEF) for the small G-Protein Ras. PLD activity is up-regulated when cells are stimulated by hormones, growth factors or other extracellular signals. Two distinct PLDs, PLD1 and PLD2, have been identified. PLD hydrolyzes phosphatidylcholine to release phosphatidic acid, which is associated with a number of cellular responses including regulated secretion, mitogenesis and cytoskeletal changes.

ALT Names :

Phospholipase A2

Immunogen :

Recombinant cPLA2

Specificity :

This antibody recognizes PLA2.

Package Size :

100 μg

Uses :

Western Blotting;ELISA;Immunohistochemistry (Paraffin)

Storage :

Stable at 2-8°C for 1 year from date of receipt.