PHD3 Antibody, clone 188e | EMD Millipore 05-1328 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PHD3 Antibody, clone 188e

catalog :

05-1328

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

188e

reactivity :

human

application :

western blot

product information

Catalog Number :

05-1328

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-PHD3 Antibody, clone 188e

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9H6Z9

Host Name :

Mouse

Antigen :

PHD3

Clone :

188e

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-PHD3 Antibody, clone 188e

Cross Reactivity :

Human

Background :

PHD3 (Prolyl hydroxylase domain-containing protein 3), also known as Hypoxia-inducible factor prolyl hydroxylase 3 (HIF-PH3 or HPH-1), is one of 4 PHD (PHD1-4) proteins which function as prolyl hydroxylases to effect oxygen homeostasis via hypoxia-inducible factor (HIF). This transcriptional complex is composed of an alpha-beta heterodimer that mediates a broad range of cellular and systemic responses to hypoxia. The PHD proteins hydroxylate HIF-1 alpha at 'Pro-402' and 'Pro-564', and HIF-2 alpha. PHD3, is expressed in response to hypoxia and causes apoptosis in oxygenated conditions in neural cells. When oxygen levels are normal, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha. This post-translational modification targets this protein for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

ALT Names :

EGL nine (C.elegans) homolog 3;HIF prolyl hydroxylase 3;HIF-prolyl hydroxylase 3;Hypoxia-inducible factor prolyl hydroxylase 3;Prolyl hydroxylase domain-containing protein 3;egl nine homolog 3;egl nine homolog 3 (C. elegans);egl nine-like protein 3 isoform

Immunogen :

Recombinant protein corresponding to human PHD3.

Specificity :

This antibody recognizes PHD3.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt