acetyl Histone H3 (Lys14), clone 10H8.2 | EMD Millipore 05-1311 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl Histone H3 (Lys14), clone 10H8.2

catalog :

05-1311

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H8.2

reactivity :

human

application :

western blot

product information

Catalog Number :

05-1311

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl Histone H3 (Lys14), clone 10H8.2

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

NP_003520.1

Host Name :

Clone :

10H8.2

Conjugate :

Purified

Isotype :

IgG1kappa

Product Description :

Anti-acetyl Histone H3 (Lys14), clone 10H8.2

Cross Reactivity :

Human

Species Summary :

Based on sequence homology, broad species cross-reactivity is expected.

Background :

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the ""histone code"" hypothesis). Histone H3 is acetylated on Lys14 by Gcn5, and histone H3 phosphorylation at Ser10 facilitates acetylation of Lys14 by Gcn5 in vitro. Moreover, Lys14 is involved in chromatin remodeling, and RSC4 (part of the RSC chromatin remodeling complex) contains essential tandem bromodomains that require H3 Lys14 acetylation for gene activation.

ALT Names :

H3K14Ac, Histone H3 (acetyl K14), HIST1H3

Immunogen :

KLH-conjugated, synthetic peptide containing the sequence (ARKSTGGA(Acetyl-K) APRGC, corresponding to the sequence surrounding acetylated lysine 14 of human histone H3.

Specificity :

Recognizes histone H3 acetylated on Lys14, Mr 17 kDa.

Purity :

Protein G purfied

Package Size :

100 ug

Uses :

Storage :

Stable for 1 year at 2-8°C from date of receipt.For maximum recovery of product, centrifuge the vial prior to removing the cap.