acetyl Histone H4 (Lys16) Antibody, clone 4E10.2 | EMD Millipore 05-1232 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl Histone H4 (Lys16) Antibody, clone 4E10.2

catalog :

05-1232

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E10.2

reactivity :

human

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000	Penicud K, Behrens A. DMAP1 is an essential regulator of ATM activity and function. Oncogene. 2014;33:525-31 pubmed publisher

product information

Catalog Number :

05-1232

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P62805

Host Name :

Mouse

Antigen :

acetyl Histone H4 (Lys16)

Clone :

4E10.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-acetyl Histone H4 (Lys16) Antibody, clone 4E10.2

Cross Reactivity :

Human

Background :

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. Histone modifications regulate DNA transcription, repair, recombination, and replication. The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination. These modifications can alter local chromatin architecture, or recruit trans-acting factors that recognize specific histone modifications (the "histone code" hypothesis). Global loss of acetylation at Lys16 is a common hallmark of human tumor cells, suggesting a role for acetylated Lys16 in preventing cell transformation. Moreover, Lys16 is the only histone mark that has been directly linked to chromatin refolding and maintainence of chromatin structure. The Sir3 protein helps form telomeric heterochromatin by interacting with hypoacetylated histone H4 Lys16 while the MYST-like acetyltransferase Sas2p is required for the acetylation H4-Lys16 in euchromatin.

ALT Names :

H4K16Ac;Histone H4 (acetyl K16);HIST1H4

Immunogen :

KLH-conjugated, synthetic peptide containing the sequence (GKGGA[acetyl-K]RHRKC, corresponding to the sequence surrounding acetylated lysine 16 of human histone H4.

Specificity :

Recognizes histone H3 acetylated on Lys16, Mr 11 kDa.

Package Size :

100 μg

Uses :

Western Blotting;Peptide Inhibition Assay

Storage :

Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.