Progerin Antibody, clone 13A4 | EMD Millipore 05-1231 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Progerin Antibody, clone 13A4

catalog :

05-1231

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

13A4

The same clone is also sold as:

MilliporeSigma: SAB4200272
Abcam: ab66587
Enzo Life Sciences: ALX-804-662-R200

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human western blot; human	Pacheco L, Gomez L, Dias J, Ziebarth N, Howard G, Schiller P. Progerin expression disrupts critical adult stem cell functions involved in tissue repair. Aging (Albany NY). 2014;6:1049-63 pubmed
	Ziegler A, Chidambaram S, Forbes B, Wood T, Levison S. Insulin-like growth factor-II (IGF-II) and IGF-II analogs with enhanced insulin receptor-a binding affinity promote neural stem cell expansion. J Biol Chem. 2014;289:4626-33 pubmed publisher
	Buono K, Vadlamuri D, Gan Q, Levison S. Leukemia inhibitory factor is essential for subventricular zone neural stem cell and progenitor homeostasis as revealed by a novel flow cytometric analysis. Dev Neurosci. 2012;34:449-62 pubmed publisher
	Mihaliak A, Gilbert C, Li L, Daou M, Moser R, Reeves A, et al. Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres. Cancer Lett. 2010;296:168-77 pubmed publisher
	Zacchigna S, Oh H, Wilsch Bräuninger M, Missol Kolka E, Jászai J, Jansen S, et al. Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration. J Neurosci. 2009;29:2297-308 pubmed publisher

product information

Catalog Number :

05-1231

Subcategory :

Cell Structure

Product Name :

Anti-Progerin Antibody, clone 13A4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q6UYC3

Host Name :

Mouse

Antigen :

Progerin

Clone :

13A4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Progerin Antibody, clone 13A4

Cross Reactivity :

Human

Background :

Progerin is a truncated version of lamin A protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a mutation (C1824T) in the lamin A gene, LMNA. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a deletion of 50 amino acids. Lamin A constitutes a major structural component of the lamina, a scaffold of proteins found inside the nuclear membrane of a cell; progerin does not properly integrate into the lamina, which disrupts the scaffold structure and leads to significant disfigurement of the nucleus, characterized by a lobular shape. Researchers have shown that progerin activates genes that regulate stem cell differentiation via the Notch signaling pathway. Progerin, which has been linked to normal aging, is produced in healthy indivduals via "sporadic use of the cryptic splice site.

ALT Names :

LMNA;CMD1A;LMNC;LMN1;LDP1;LFP;FPLD;FPL;EMD2

Immunogen :

KLH-conjugated synthetic peptide corresponding to the amino acids 604-611 of progerin (lamin A/C).

Specificity :

Recognizes human progerin, Mr ~70 kDa. Does not recognize Lamin A or Lamin C

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry;ELISA;Immunoprecipitation

Storage :

Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.