PDGFR Antibody, clone CH-3 | EMD Millipore 05-1135 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PDGFR Antibody, clone CH-3

catalog :

05-1135

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CH-3

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; fig 3 western blot; human; fig 3	Yu D, Makkar G, Strickland D, Blanpied T, Stumpo D, Blackshear P, et al. Myristoylated Alanine-Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation. J Am Heart Assoc. 2015;4:e002255 pubmed publisher

product information

Catalog Number :

05-1135

Subcategory :

Cell Signaling

Product Name :

Anti-PDGFR Antibody, clone CH-3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P09619

Host Name :

Mouse

Antigen :

PDGFR

Clone :

CH-3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-PDGFR Antibody, clone CH-3

Cross Reactivity :

Human;Mouse;Rat

Background :

PDGFR (Platelet-Derived Growth Factor Receptor) is a receptor tyrosine kinase for the PDGF family of growth factors. PDGF homo and hetero- dimmers (dimer of A (17 kDa) and B (14 kDa) chains (AA, AB, or BB)) bind to the two structurally related a and b PDGF Receptors (PDGFRa and PDGFRb). The type A PDGF Receptor binds all three PDGFs with high affinity, whereas the type B PDGF Receptor is selective for PDGF-BB. This binding results in the dimerization of the receptor and the subsequent kinase activation of the receptor tyrosine kinase (RTK) and its autophosphorylation. These phosphorylations allow for various proteins, such as PI3 Kinase, PLCg, and Grb2, to bind through their SH2 domains and transduce signals into the cell. The activation of PDGFFR triggers the intracellular loop and activates Ras, Erk1/2, and ROS. PDGFb has been implicated in embryonic development, angiogenesis, and development of tumors of glial origin.

ALT Names :

Platelet Derived Growth Factor Receptor Beta;PDGF-R-beta;PDGFR-beta;Beta platelet-derived growth factor receptor;Beta-type platelet-derived growth factor receptor;CD140 antigen-like family member B;Platelet-derived growth factor receptor 1;PDGFR-1;CD140b

Immunogen :

Recombinant Platelet-Derived Growth Factor Receptor

Package Size :

100 μg

Uses :

Western Blotting;ELISA;Immunohistochemistry (Paraffin)

Storage :

Maintain at + 2-8 ° C in undiluted aliquots for up to 1 year from date of receipt.