erbB4 Antibody, clone HFR1/2G4 | EMD Millipore 05-1133 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

erbB4 Antibody, clone HFR1/2G4

catalog :

05-1133

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HFR1/2G4

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 1

Reference
Pankratova S, Klingelhofer J, Dmytriyeva O, Owczarek S, Renziehausen A, Syed N, et al. The S100A4 Protein Signals through the ErbB4 Receptor to Promote Neuronal Survival. Theranostics. 2018;8:3977-3990 pubmed publisher

product information

Catalog Number :

05-1133

Subcategory :

Cell Signaling

Product Name :

Anti-erbB4 Antibody, clone HFR1/2G4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15303

Host Name :

Mouse

Antigen :

erbB4

Clone :

HFR1/2G4

Conjugate :

Purified

Isotype :

IgG 1 κ

Product Description :

Anti-erbB4 Antibody, clone HFR1/2G4

Cross Reactivity :

Human;Mouse;Rat

Background :

v-ErbB was identified as the viral counterpart of the EGF Receptor, and its relatives have adopted this nomenclature (or the HER nomenclature for human proteins). These proteins are activated by Heregulin, Neuregulin and Amphiregulin. ErbB-2/HER-2, also known as neu, is amplified in large numbers of highly aggressive breast cancers, but all the family members are capable of heterodimerization, and together activate downstream signaling pathways. ErbB-3 has a natural "substitution" at the codon which is an invariant Lys residue at the ATP-binding site of all protein kinases. It is therefore inactive as a kinase, and can only become phosphorylated by heterodimerization with another erbB-family member. All members of this family, when Tyr-phosphorylated, can nucleate the formation of signaling complexes through adapter proteins.

Immunogen :

Synthetic peptide sequence RSTLQHPDYLQEYST from the cytoplasmic domain of the protein, residues 1250-1264.

Specificity :

Reactive with human c-erB-4/Her 4 cytoplasmic domain of the protein (residues 1250-1264), a member of the EGF receptor (type 1) family involved in cell growth regulation. Expression or function may be altered in human cancers.

Package Size :

100 µg

Uses :

Western Blotting;Immunoprecipitation;Immunohistochemistry (Paraffin)

Storage :

Stable refrigerated at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.