IGF-IR Antibody, β-subunit, clone 1-2 | EMD Millipore 05-1106 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IGF-IR Antibody, β-subunit, clone 1-2

catalog :

05-1106

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1-2

The same clone is also sold as:

Invitrogen: MA5-13822
LifeSpan Biosciences: LS-C88327, LS-C88328
Enzo Life Sciences: BML-SA369-0100

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

05-1106

Subcategory :

Cell Signaling

Product Name :

Anti-IGF-IR Antibody, β-subunit, clone 1-2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08069

Host Name :

Mouse

Antigen :

IGF-IR

Clone :

1-2

Conjugate :

Affinity Purified

Isotype :

IgG2b

Product Description :

Anti-IGF-IR Antibody, β-subunit, clone 1-2

Cross Reactivity :

Human;Rat;Mouse

Background :

IGF-I and -II signal through the IGF-I Receptor, which is homologous to the Insulin Receptor. The high-affinity IGF-II Receptor does not play a direct role in signaling, but regulates the concentration of free IGF-II. The IGFs are involved in skeletal growth, and are essential for prevention of apoptosis. Serum levels of free IGFs are kept low by the action of IGF binding proteins (IGFBPs), which sequester the IGFs. Overexpression of IGFBPs may induce apoptosis, presumably by reduction of free IGF; IGFBP levels are also altered in some cancers. The IGF-I Receptor is not as mitogenic as some other growth factor receptors, but its ability to activate the PI3 Kinase pathway, through the Insulin Receptor Substrate (IRS) proteins, is critical for mediating cell survival.

Immunogen :

A 15-mer peptide corresponding to a.a. 1323-1337 (Tyr-RKNERALPLPQSSTC) from the C-terminal of β-subunit of human IGF-1R.

Specificity :

Recognizes the β-subunit of type I Insulin-like Growth Factor Receptor (IGF-1R). It shows no cross-reaction with insulin receptor. Its epitope localizes between a.a. 1323-1337 of IGF-1R. Both IGF-1R and insulin receptor are synthesized as a single polypeptide which is glycosylated and proteolytically cleaved to give the α- and β-subunits, which are disulfide-linked in a β-α-α-β configuration in the mature receptor. The α-subunit is completely extracellular, while the β-subunit spans membrane.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.