Insulin Receptor (β-Subunit) Antibody, clone CT-3 | EMD Millipore 05-1104 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Insulin Receptor (β-Subunit) Antibody, clone CT-3

catalog :

05-1104

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CT-3

The same clone is also sold as:

Enzo Life Sciences: BML-SA432-0100
LifeSpan Biosciences: LS-C88312, LS-C24738, LS-C101322
Santa Cruz Biotechnology: sc-57342
Invitrogen: AHR0271, MA5-13783

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 5

Reference
Li J, Xu L, Dong H, Huang Z, Zhao Y, Chen G, et al. Effects of Chinese Fructus Mume formula and its separated prescription extract on insulin resistance in type 2 diabetic rats. J Huazhong Univ Sci Technolog Med Sci. 2013;33:877-885 pubmed publisher
Stuart C, South M, Lee M, McCurry M, Howell M, Ramsey M, et al. Insulin responsiveness in metabolic syndrome after eight weeks of cycle training. Med Sci Sports Exerc. 2013;45:2021-9 pubmed publisher
Bobrich M, Schwabe S, Brobeil A, Viard M, Kamm M, Mooren F, et al. PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. J Obes. 2013;2013:476240 pubmed publisher
Stuart C, McCurry M, Marino A, South M, Howell M, Layne A, et al. Slow-twitch fiber proportion in skeletal muscle correlates with insulin responsiveness. J Clin Endocrinol Metab. 2013;98:2027-36 pubmed publisher
Krishnapuram R, Dhurandhar E, Dubuisson O, Kirk Ballard H, Bajpeyi S, Butte N, et al. Template to improve glycemic control without reducing adiposity or dietary fat. Am J Physiol Endocrinol Metab. 2011;300:E779-89 pubmed publisher

product information

Catalog Number :

05-1104

Subcategory :

Cell Signaling

Product Name :

Anti-Insulin Receptor (β-Subunit) Antibody, clone CT-3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P06213

Host Name :

Mouse

Antigen :

Insulin Receptor (β-Subunit)

Clone :

CT-3

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Insulin Receptor (β-Subunit) Antibody, clone CT-3

Cross Reactivity :

Human;Monkey;Mouse;Rat

Background :

The insulin receptor is a tyrosine kinase receptor that when bound to insulin, initiates multiple signal transduction pathways, including JNK, PI 3-kinase, Akt and PKC. Pharmacological intervention of these Insulin R-dependent pathways is of great interest for the treatment of insulin resistance, obesity and diabetes. The Insulin Receptor (IR) is synthesized as a single polypeptide, which is subsequently cleaved to generate an extracellular α-chain and a transmembrane and intracellular β-chain, tethered together by disulfide bonds. The β-chain has multiple tyrosine phosphorylation sites, including three autophosphorylation sites at its activation loop. The overall structure of the IR is highly homologous to the IGF-I Receptor, except in their c-termini, where the two proteins diverge somewhat. The IR signals primarily by phosphorylating the Insulin Receptor Substrate (IRS) family of proteins, which creates docking sites for SH2-domain containing proteins. Insulin signaling is highly dependent on the PI3 Kinase pathway and Akt, which appear to mediate the functions of insulin.

Immunogen :

Recombinant-fragment including the C-terminal 100 amino acids of human insulin receptor, β subunit.

Specificity :

Recognizes a protein of 95 kDa, identified as the β-subunit of insulin receptor (IR). It is directed against the C-terminal region of β-subunit and shows no cross-reaction with IGF-receptors.

Package Size :

100 μg

Uses :

ELISA;Enzyme Assay;Western Blotting;Immunohistochemistry (Paraffin);Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C in undiluted aliquots from date of receipt.