acetyl CoA Carboxylase Antibody, clone 7D2.2 | EMD Millipore 05-1098 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

acetyl CoA Carboxylase Antibody, clone 7D2.2

catalog :

05-1098

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

7D2.2

reactivity :

human

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 6c	Trousil S, Kaliszczak M, Schug Z, Nguyen Q, Tomasi G, Favicchio R, et al. The novel choline kinase inhibitor ICL-CCIC-0019 reprograms cellular metabolism and inhibits cancer cell growth. Oncotarget. 2016;7:37103-37120 pubmed publisher
	Rowe I, Chiaravalli M, Mannella V, Ulisse V, Quilici G, Pema M, et al. Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy. Nat Med. 2013;19:488-93 pubmed publisher

product information

Catalog Number :

05-1098

Subcategory :

Cell Signaling

Product Name :

Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13085

Host Name :

Mouse

Antigen :

acetyl CoA Carboxylase

Clone :

7D2.2

Conjugate :

Purified

Isotype :

IgG2aκ

Product Description :

Anti-acetyl CoA Carboxylase Antibody, clone 7D2.2

Cross Reactivity :

Human;Rat

Background :

Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes carboxylation of acetyl-CoA to produce malonyl-CoA through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT). ACC is a multi-subunit enzyme in most prokaryotes, whereas it is a large, multi-domain enzyme in most eukaryotes. The activity of ACC can be controlled at the transcriptional level as well as by small molecule modulators and covalent modification. The human genome contains the genes for two different ACCs - ACACA and ACACB. The activity of the enzyme is controlled by reversible phosphorylation. The activity of the enzyme is inhibited if phosphorylated; the phosphorylation takes place when the hormone glucagon or epinephrine binds to the receptors or the energy status of the cell is low, leading to the activation of the AMP-activated protein kinase. The presence of fatty acid inhibits the activities of the enzyme. When insulin binds to its receptors, it activates a phosphatase to dephosphorylate the enzyme; the activities of the acetyl-CoA carboxylase is thus enhanced. Acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity and antibiotic drugs.

ALT Names :

acetyl-CoA carboxylase 1;acetyl-CoA carboxylase-alpha;acetyl-Coenzyme A carboxylase alpha

Immunogen :

Histidine-tagged recombinant protein corresponding to human acetyl CoA Carboxylase.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt