c-Jun Antibody, clone 6E4.4 | EMD Millipore 05-1076 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

c-Jun Antibody, clone 6E4.4

catalog :

05-1076

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6E4.4

reactivity :

human, mouse

application :

western blot, immunocytochemistry

citations: 2

Reference
Chakrabarti S, Davidge S. G-protein coupled receptor 30 (GPR30): a novel regulator of endothelial inflammation. PLoS ONE. 2012;7:e52357 pubmed publisher
Chakrabarti S, Davidge S. Estradiol modulates tumor necrosis factor-induced endothelial inflammation: role of tumor necrosis factor receptor 2. J Vasc Res. 2013;50:21-34 pubmed publisher

product information

Catalog Number :

05-1076

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-c-Jun Antibody, clone 6E4.4

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P45983

Host Name :

Mouse

Antigen :

c-Jun

Clone :

6E4.4

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-c-Jun Antibody, clone 6E4.4

Cross Reactivity :

Human;Mouse;Rat

Background :

c-Jun is a component of the transcription factor AP-1 that binds and activates transcription at TRE/AP-1 elements and appears to be a major downstream target of the SAPK/JNK signaling pathway. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73. Extracellular signals including growth factors, transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun dependent transcription. Mutation of Ser63/73 renders c-Jun nonresponsive to mitogenic and stress induced signaling pathways. The MAP kinase homologue, SAPK/JNK, binds to the N-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73. In addition, the activity of SAPK/JNK is stimulated by the same signals that activate c-Jun.

ALT Names :

JNK1 alpha protein kinase ;JNK1 beta protein kinase ;JUN N-terminal kinase ;Stress-activated protein kinase JNK1 ;c-Jun N-terminal kinase 1 ;mitogen-activated protein kinase 8 ;mitogen-activated protein kinase 8 isoform JNK1 alpha1 ;mitogen-activated protein kinase 8 isoform JNK1 beta2 ;protein kinase JNK1

Immunogen :

GST-tagged recombinant protein corresponding to c-Jun.

Specificity :

This antibody detects c-Jun, regardless of phosphorylation state.

Package Size :

100 µg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable at 2-8°C for 1 year from date of receipt.