FOXO1 Antibody, clone 2H8.2 | EMD Millipore 05-1075 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FOXO1 Antibody, clone 2H8.2

catalog :

05-1075

quantity :

200 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2H8.2

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:100	Tamura K, Minami K, Kudo M, Iemoto K, Takahashi H, Seino S. Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. PLoS ONE. 2015;10:e0126003 pubmed publisher
western blot; human	Dessalle K, Euthine V, Chanon S, Delarichaudy J, Fujii I, Rome S, et al. SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors. PLoS ONE. 2012;7:e50878 pubmed publisher

product information

Catalog Number :

05-1075

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-FOXO1 Antibody, clone 2H8.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q12778

Host Name :

Mouse

Antigen :

FOXO1

Clone :

2H8.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-FOXO1 Antibody, clone 2H8.2

Cross Reactivity :

Human;Mouse;Rat

Background :

Forkhead box O (FOXO) transcription factors play an important role in modulating metabolic functions. Given the relatively high expression of FOXO1 in insulin-responsive tissues, this transcription factor is highly poised to regulate energy metabolism. When nutrient and insulin levels are low, FOXO1 promotes expression of gluconeogenic enzymes. Conversely, in the fed state, insulin levels rise and stimulate uptake of glucose primarily into skeletal muscle and other organs, including adipose tissue. Under certain pathophysiologic conditions, including insulin resistance, negative signaling to FOXO1 is compromised. (Gross, D.N., 2009).

ALT Names :

Forkhead box protein O1A ;Forkhead in rhabdomyosarcoma;forkhead box O1 ;forkhead box O1A (rhabdomyosarcoma);forkhead homolog in rhabdomyosarcoma ;forkhead, Drosophila, homolog of, in rhabdomyosarcoma

Immunogen :

GST-tagged recombinant protein corresponding to full length FOXO1.

Specificity :

This antibody detects FOXO1. FOXO1 shuttles between the nucleus and the cytosol.

Package Size :

200 µg

Uses :

Western Blotting;Immunocytochemistry;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8ºC from date of receipt.