phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal | EMD Millipore 05-1059 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal

catalog :

05-1059

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

8.78.8

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunohistochemistry - frozen section

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; tbl 4	Lopes M, Leal R, Guarnieri R, Schwarzbold M, Hoeller A, Diaz A, et al. A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system. Transl Psychiatry. 2016;6:e986 pubmed publisher
western blot; human; loading ...; fig s1	Tai Y, Tung L, Lin Y, Lu P, Chu P, Wang M, et al. Grb7 Protein Stability Modulated by Pin1 in Association with Cell Cycle Progression. PLoS ONE. 2016;11:e0163617 pubmed publisher
immunohistochemistry - frozen section; human	Saghizadeh M, Dib C, Brunken W, Ljubimov A. Normalization of wound healing and stem cell marker patterns in organ-cultured human diabetic corneas by gene therapy of limbal cells. Exp Eye Res. 2014;129:66-73 pubmed publisher

product information

Catalog Number :

05-1059

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q15759

Host Name :

Rabbit

Antigen :

phospho-p38α(Thr180/Tyr182)

Clone :

8.78.8

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Vertebrates

Background :

The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation.

ALT Names :

CSAID-binding protein;Csaids binding protein ;Cytokine suppressive anti-inflammatory drug-binding protein ;MAP kinase MXI2;MAP kinase p38 alpha;MAX-interacting protein 2;Mitogen-activated protein kinase p38 alpha ;cytokine suppressive anti-inflammatory drug binding protein;mitogen-activated protein kinase 14;p38 MAP kinase;p38 mitogen activated protein kinase;p38alpha Exip ;stress-activated protein kinase 2A

Immunogen :

Synthetic peptide corresponding to amino acids surrounding and including phosphorylated Thr180/Tyr182 of human p38α.

Specificity :

This antibody detects p38α when phosphorylated on Thr180/Tyr182.

Package Size :

100 µL

Uses :

Western Blotting;Immunofluorescence

Storage :

Stable for 1 year at -20ºC from date of receipt.