phospho-PTEN (Ser380) Antibody, clone 5.15.12, rabbit monoclonal | EMD Millipore 05-1056 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-PTEN (Ser380) Antibody, clone 5.15.12, rabbit monoclonal

catalog :

05-1056

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

5.15.12

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

05-1056

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-PTEN (Ser380) Antibody, clone 5.15.12, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P60484

Host Name :

Rabbit

Antigen :

phospho-PTEN (Ser380)

Clone :

5.15.12

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-PTEN (Ser380) Antibody, clone 5.15.12, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat;Vertebrates

Background :

The protein and lipid phosphatase PTEN (phosphatase and tensin homolog deleted on chromosome ten) has been suggested to play a role in tumorgenesis. PTEN is a tumor suppressor whose loss permits constitutive signaling through the PI3K pathway and is sufficient to cause cancer. In normal cells, FOXO1A and PTEN function together to restrain cell growth. PTEN metabolizes PI(3,4,5)P3, the product of PI3K phosphorylation of PI(4,5)P2 following receptor activation. In cells lacking PTEN, there is an elevated level of PI(3,4,5)P3, which acts as a potent second messenger promoting oncogenesis. Restoration of PTEN function is considered a novel approach to cancer therapy. Overexpression of PTEN inhibits cell migration, and expression of antisense PTEN mRNA enhances migration.

ALT Names :

MMAC1 phosphatase and tensin homolog deleted on chromosome;Mutated in multiple advanced cancers 1;phosphatase and tensin homolog

Immunogen :

Synthetic peptide corresponding to amino acids surrounding phosphorylated Ser380 of human PTEN.

Specificity :

This antibody detects PTEN when phosphorylated on Ser380.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.