ILK Antibody, clone 6G6.3 | EMD Millipore 05-1051 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ILK Antibody, clone 6G6.3

catalog :

05-1051

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6G6.3

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

05-1051

Subcategory :

Cell Signaling

Product Name :

Anti-ILK Antibody, clone 6G6.3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13418

Host Name :

Mouse

Antigen :

ILK

Clone :

6G6.3

Conjugate :

Purified

Isotype :

IgG3κ

Product Description :

Anti-ILK Antibody, clone 6G6.3

Cross Reactivity :

Mouse;Human;Rat

Background :

ILK (Integrin-Linked Kinase) is an intraceullar Ser/Thr kinase with four Ankyrin-like repeats. It is known to play pivotal roles in extracellular matrix mediated signaling. ILK is known to associate with β-Integrins in addition to many other focal adhesion associated proteins. In this context, ILK is involved cell adhesion/migration. The kinase activity appears to be reduced following Integrin activation, and overexpression of p59ILK inhibits cellular adhesion to Integrin substrates. Additionally, ILK has been associated with epithelial mesechymal transition (EMT) in a TGF-β1 induced Smad dependent manner (Li, 2003). Forced expression of ILK also induced the expression of MMP-2 (matrix metalloprotease 2) and promoted cell migration and invasion (Li, 2003).

ALT Names :

Integrin-Linked Kinase;p59;DKFZp686F1765;p59ILK

Immunogen :

Full length recombinant GST-tagged human ILK.

Specificity :

Recognizes ILK

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at 2-8°C.