Met (extracellular) Antibody, clone 4F8.2 | EMD Millipore 05-1049 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Met (extracellular) Antibody, clone 4F8.2

catalog :

05-1049

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4F8.2

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Boyd N, Nunes S, Krishnan L, Jokinen J, Ramakrishnan V, Bugg A, et al. Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments. Tissue Eng Part A. 2013;19:211-23 pubmed publisher

product information

Catalog Number :

05-1049

Subcategory :

Cell Signaling

Product Name :

Anti-Met (extracellular) Antibody, clone 4F8.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08581

Host Name :

Mouse

Antigen :

Met (extracellular)

Clone :

4F8.2

Conjugate :

Purified

Isotype :

IgG2bκ

Product Description :

Anti-Met (extracellular) Antibody, clone 4F8.2

Cross Reactivity :

Human

Background :

The proto-oncogene Met (c-Met, HGF/SF Receptor, HGFR) is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. This stimulates the autophosphorylation on Tyr1234/Tyr1235 which leads to pleiotropic downstream signaling events in epithelial cells that stimulate multiple cellular processes including cell proliferation, growth, differentiation, cell migration/ invasion, and tumorigenesis. These effects are mediated by SH2 domain-containing proteins that bind to the C-terminal tail of c-Met. Chronic stimulation of Met on cancer cells is thought to play a role in metastasis and dysregulation of c-Met activity is directly associated with oncogenesis, making it an important cancer target.

ALT Names :

HGF receptor ;HGF/SF receptor;Met proto-oncogene tyrosine kinase;SF receptor ;Scatter factor receptor;met proto-oncogene ;met proto-oncogene (hepatocyte growth factor receptor);oncogene MET

Immunogen :

GST-fusion protein corresponding to amino acids 80-434 of human Met.

Specificity :

Detects Met on its extracellular domain.

Package Size :

100 μg

Uses :

Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.