phospho-EGFR (Tyr1173) Antibody, clone 3G3.2 | EMD Millipore 05-1004 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-EGFR (Tyr1173) Antibody, clone 3G3.2

catalog :

05-1004

quantity :

100 µg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G3.2

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

citations: 2

Reference
Turtoi A, Blomme A, Bellahcene A, Gilles C, Hennequière V, Peixoto P, et al. Myoferlin is a key regulator of EGFR activity in breast cancer. Cancer Res. 2013;73:5438-48 pubmed publisher
Hwang Y, Lee S, Park K, Chung W. Secretion of IL-6 and IL-8 from lysophosphatidic acid-stimulated oral squamous cell carcinoma promotes osteoclastogenesis and bone resorption. Oral Oncol. 2012;48:40-8 pubmed publisher

product information

Catalog Number :

05-1004

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-EGFR (Tyr1173) Antibody, clone 3G3.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q86T13

Host Name :

Mouse

Antigen :

phospho-EGFR (Tyr1173)

Clone :

3G3.2

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-phospho-EGFR (Tyr1173) Antibody, clone 3G3.2

Cross Reactivity :

Human

Background :

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. EGFR (epidermal growth factor receptor) exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). EGFR dimerization stimulates its intrinsic intracellular protein-tyrosine kinase activity. As a result, autophosphorylation of five tyrosine (Y) residues in the C-terminal domain of EGFR occurs.

ALT Names :

C-type lectin domain family 14, member A;ClECT and EGF-like domain containing protein ;Epidermal growth factor receptor 5;chromosome 14 open reading frame 27

Immunogen :

KLH-conjugated linear peptide corresponding to residues surrounding Tyr1173 of EGFR.

Specificity :

This antibody recognizes phosphorylated EGFR (Tyr1173).

Package Size :

100 µg

Uses :

Western Blotting;Flow Cytometry;Immunohistochemistry;Immunocytochemistry

Storage :

Maintain refrigerated at 2-8°C for 1 year from date of receipt.