Osteopontin Antibody, clone 6B6.2 | EMD Millipore 04-970 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Osteopontin Antibody, clone 6B6.2

catalog :

04-970

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

6B6.2

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

04-970

Subcategory :

Cell Signaling

Product Name :

Anti-Osteopontin Antibody, clone 6B6.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P10451

Host Name :

Mouse

Antigen :

Osteopontin

Clone :

6B6.2

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-Osteopontin Antibody, clone 6B6.2

Cross Reactivity :

Human;Mouse

Background :

Osteopontin is a single-chain polypeptide. It is highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It is characterized by the presence of a polyaspartic acid sequence and sites of Ser/Thr phosphorylation that mediate hydroxyapatite binding, and a highly conserved RGD motif that mediates cell attachment/signaling. Expression of osteopontin in a variety of tissues indicates a multiplicity of functions that involve one or more of these conserved motifs. While the lack of a clear phenotype in osteopontin "knockout" mice has not established a definitive role for osteopontin in any tissue, recent studies have provided some novel and intriguing insights into the versatility of this enigmatic protein in diverse biological events, including developmental processes, wound healing, immunological responses, tumorigenesis, bone resorption, and calcification. The ability of osteopontin to stimulate cell activity through multiple receptors linked to several interactive signaling pathways can account for much of the functional diversity.

ALT Names :

Bone sialoprotein 1;SPP1/CALPHA1 fusion;Urinary stone protein;bone sialoprotein I;osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein;secreted phosphoprotein 1;secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1);secreted phosphoprotein-1 (osteopontin, bone sialoprotein);Uropontin;osteopontin

Immunogen :

KLH-conjugated linear peptide corresponding to the C-terminus of human Osteopontin.

Specificity :

This antibody recognizes Osteopontin at the C-terminus.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt