Interleukin 12 (IL-12) Antibody, clone 8.6 | EMD Millipore 04-961 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Interleukin 12 (IL-12) Antibody, clone 8.6

catalog :

04-961

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8.6

reactivity :

human

application :

flow cytometry

product information

Catalog Number :

04-961

Subcategory :

Inflammation & Immunology

Product Name :

Anti-Interleukin 12 (IL-12) Antibody, clone 8.6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P29460

Host Name :

Mouse

Antigen :

Interleukin 12 (IL-12)

Clone :

8.6

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-Interleukin 12 (IL-12) Antibody, clone 8.6

Cross Reactivity :

Human

Background :

Interleukin 12 (IL-12) is an interleukin produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) and is involved in the differentiation of naive T cells into Th1 cells or Th2 cells. IL-12 is a heterodimeric cytokine comprised of p35 and p40 subunits and is considered a T cell stimulating factor. IL-12 stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T and natural killer (NK) cells and reduces IL-4 mediated suppression of IFN-γ. IL-12 can also block the formation of new blood vessels through its induction cascade and is a possible target for anti-cancer drug screening. IL-12 may play a role in autoimmunity by worsening the autoimmune response, due to its key role in induction of Th1 immune responses. Whereas, IL-12 gene knock-out in mice or a treatment of mice with IL-12 specific antibodies seems to ameliorate the diseases.

ALT Names :

CLMF p40;Cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;IL12, subunit p40;NK cell stimulatory factor chain 2;interleukin 12, p40;interleukin 12B;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 beta chain;natural killer cell stimulatory factor, 40 kD subunit

Immunogen :

Purified human IL-12, p40 subunit.

Specificity :

This antibody recognizes IL-12, subunit p40.

Package Size :

100 μg

Uses :

Flow Cytometry

Storage :

Stable for 1 year at 2-8°C from date of receipt