FOXP3 Antibody, clone 3G3 | EMD Millipore 04-960 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

FOXP3 Antibody, clone 3G3

catalog :

04-960

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3G3

The same clone is also sold as:

LifeSpan Biosciences: LS-C148080, LS-C112621, LS-C47269, LS-C368324, LS-C112622
Santa Cruz Biotechnology: sc-52899
MilliporeSigma: SAB4700610, SAB4700611
Novus Biologicals: NB100-56582, NBP2-33297
Exbio: 11-601-C025, A4-601-C100, 1P-601-C100, 1A-601-C100, 11-601-C100, 1P-601-C025, A4-601-C025, A6-601-C025, A6-601-C100, 1A-601-C025
Abnova: MAB0107, MAB9852
Tonbo Biosciences: 35-5773
Invitrogen: MA5-18160, MA1-10332, MA5-16224, MA5-16222, MA1-41628, A18662, MA5-18159, A18690
OriGene: AM12131PU-N, TA336416

reactivity :

human, mouse

application :

flow cytometry

product information

Catalog Number :

04-960

Subcategory :

Inflammation & Immunology

Product Name :

Anti-FOXP3 Antibody, clone 3G3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q99JB6

Host Name :

Mouse

Antigen :

FOXP3

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-FOXP3 Antibody, clone 3G3

Cross Reactivity :

Mouse;Human

Background :

The regulation of tolerance to self-antigens is a necessary biological process in order to prevent autoimmunity. CD4+ CD25+ regulatory T cells are known regulators of immune tolerance and activation. In both human and mice species, CD4+ CD25+ regulatory T cells are consistent in their expression of the transcription factor FOXP3 (forkhead box P3). FOXP3 acts as the “master switch” for the function and development of regulatory T cells. Mutations and deletions in the sequence encoding for FOXP3 expression lead to an inability to express FOXP3, causing an inability to regulate T cell development and leading to fatal autoimmune diseases such as IPEX and XLAAD. Conversely, recent studies have shown high and wide expression of FOXP3 in several cancer cell lines and tumors, indicating that FOXP3 is involved in preventing immunity against malignant tumors.

ALT Names :

forkhead box P3;immune dysregulation, polyendocrinopathy, enteropathy, X-linked;immunodeficiency, polyendocrinopathy, enteropathy, X-linked

Immunogen :

Histadine-tagged recombinant protein corresponding to the N-terminus of mouse FOXP3.

Specificity :

This antibody recognizes the N-terminus of Forkhead box protein P3 (FOXP3).

Package Size :

100 μg

Uses :

Flow Cytometry;ELISA

Storage :

Stable for 1 year at 2-8°C from date of receipt