GSK3α/β Antibody, rabbit monoclonal | EMD Millipore 04-903 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GSK3α/β Antibody, rabbit monoclonal

catalog :

04-903

quantity :

100 μl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; loading ...; fig s3s2	Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta M, et al. SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. elife. 2018;7: pubmed publisher

product information

Catalog Number :

04-903

Subcategory :

Cell Signaling

Product Name :

Anti-GSK3α/β Antibody, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P49840

Host Name :

Rabbit

Antigen :

GSK3α/β

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-GSK3α/β Antibody, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two isoforms exist, GSK3α and GSK3β. The function of GSK3 is to phosphorylate Glycogen Synthase and thereby inactivate it. Insulin action stimulates the PI3 Kinase pathway, resulting in Akt activation, which phosphorylates and inactivates GSK3. Glycogen Synthase is then rapidly dephosphorylated and activated. Other GSK3 substrates include Jun (on inhibitory sites), and eIF2B. Phosphorylation of Tau by GSK3 may relate to development of Alzheimer's disease. Phosphorylation state-specific antibodies directed against the Akt site (Ser21) on GSK3 are suitable for surrogate assays of the activation state of the pathway.

ALT Names :

GSK-3 alpha;glycogen synthase kinase 3 alpha

Immunogen :

N-terminal 6His-tagged recombinant full length human GSK3β.

Specificity :

GSK3 alpha and beta.

Package Size :

100 μl

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.