phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal

catalog :

04-900

quantity :

100 μl

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

NL8

reactivity :

human

application :

western blot

product information

Catalog Number :

04-900

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P08581

Host Name :

Rabbit

Antigen :

phospho-Met (Tyr1234/1235)

Clone :

NL8

Isotype :

IgG

Product Description :

Anti-phospho-Met (Tyr1234/1235) Antibody, clone NL8, rabbit monoclonal

Cross Reactivity :

Human

Background :

The proto-oncogene Met (c-Met, HGF/SF Receptor, HGFR) is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. This stimulates the autophosphorylation on Tyr1234/Tyr1235 which leads to pleiotropic downstream signaling events in epithelial cells that stimulate multiple cellular processes including cell proliferation, growth, differentiation, cell migration/ invasion, and tumorigenesis. These effects are mediated by SH2 domain-containing proteins that bind to the C-terminal tail of c-Met. Chronic stimulation of Met on cancer cells is thought to play a role in metastasis and dysregulation of c-Met activity is directly associated with oncogenesis, making it an important cancer target.

ALT Names :

HGF receptor ;HGF/SF receptor;Met proto-oncogene tyrosine kinase;SF receptor;Scatter factor receptor;met proto-oncogene ;met proto-oncogene (hepatocyte growth factor receptor);oncogene MET

Immunogen :

KLH-conjugated, synthetic peptide (…KE[pY][pY}SV…) in which pYpY corresponds to phosphorylated amino acids 1234 and 1235 of human Met/HGFR.

Specificity :

Recognizes phosphorylated Met, Mr 140 kDa. Cross-reacts with phosphorylated EGFR.

Package Size :

100 μl

Uses :

Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance