phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal

catalog :

04-886

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

A11W

reactivity :

human, mouse, bovine, chimpanzee

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; tbl s3	Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
	Woolley J, Naughton R, Stanicka J, Gough D, Bhatt L, Dickinson B, et al. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS ONE. 2012;7:e34050 pubmed publisher
	Ng L, Lyubarsky A, Nikonov S, Ma M, Srinivas M, Kefas B, et al. Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors. J Neurosci. 2010;30:3347-57 pubmed publisher

product information

Catalog Number :

04-886

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P42229

Host Name :

Rabbit

Antigen :

phospho-STAT5A/B (Tyr694/699)

Clone :

A11W

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-STAT5A/B (Tyr694/699) Antibody, clone A11W, rabbit monoclonal

Cross Reactivity :

Rat;Human;Mouse;Bovine;Chimpanzee

Background :

The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation.

ALT Names :

signal transducer and activator of transcription 5A ;signal transducer and activator of transcription 5B;transcription factor STAT5B

Immunogen :

KLH-conjugated, synthetic peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine at residue 694 of human STAT5A or residue 699 of STAT5B.

Specificity :

Phospho-STAT5A/B (Tyr694/699).

Package Size :

100 μL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.