Histone H4 Antibody, pan, rabbit monoclonal | EMD Millipore 04-858 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Histone H4 Antibody, pan, rabbit monoclonal

catalog :

04-858

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

62-141-13

reactivity :

human, mouse, brewer's yeast

application :

western blot, chromatin immunoprecipitation

citations: 19

Published Application/Species/Sample/Dilution	Reference
western blot; brewer's yeast; loading ...; fig s1e	Yu R, Sun L, Sun Y, Han X, Qin L, Dang W. Cellular response to moderate chromatin architectural defects promotes longevity. Sci Adv. 2019;5:eaav1165 pubmed publisher
chromatin immunoprecipitation; human	Huichalaf C, Micheloni S, Ferri G, Caccia R, Gabellini D. DNA methylation analysis of the macrosatellite repeat associated with FSHD muscular dystrophy at single nucleotide level. PLoS ONE. 2014;9:e115278 pubmed publisher
western blot; human; 1:10000	Dudakovic A, Camilleri E, Lewallen E, McGee Lawrence M, Riester S, Kakar S, et al. Histone deacetylase inhibition destabilizes the multi-potent state of uncommitted adipose-derived mesenchymal stromal cells. J Cell Physiol. 2015;230:52-62 pubmed publisher
western blot; human	Mücke K, Paulus C, Bernhardt K, Gerrer K, Schön K, Fink A, et al. Human cytomegalovirus major immediate early 1 protein targets host chromosomes by docking to the acidic pocket on the nucleosome surface. J Virol. 2014;88:1228-48 pubmed publisher
western blot; mouse	Schroeder F, Lewis M, Fass D, Wagner F, Zhang Y, Hennig K, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests. PLoS ONE. 2013;8:e71323 pubmed publisher
western blot; mouse	Londoño Gentile T, Lu C, Lodato P, Tse S, Olejniczak S, Witze E, et al. DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation. Mol Cell Biol. 2013;33:3864-78 pubmed publisher
western blot; human western blot; mouse	Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed publisher
	de Bruyn Kops A, Burke J, Guthrie C. Brr6 plays a role in gene recruitment and transcriptional regulation at the nuclear envelope. Mol Biol Cell. 2018;29:2578-2590 pubmed publisher
	Wang Y, Zhang J, Wu L, Liu W, Wei G, Gong X, et al. Tricho-rhino-phalangeal syndrome 1 protein functions as a scaffold required for ubiquitin-specific protease 4-directed histone deacetylase 2 de-ubiquitination and tumor growth. Breast Cancer Res. 2018;20:83 pubmed publisher
	Mo X, Zhang H, Preston S, Martin K, Zhou B, Vadalia N, et al. Interferon-γ Signaling in Melanocytes and Melanoma Cells Regulates Expression of CTLA-4. Cancer Res. 2018;78:436-450 pubmed publisher
	Dmitriev R, Papkovsky D. In vitro ischemia decreases histone H4K16 acetylation in neural cells. FEBS Lett. 2015;589:138-44 pubmed publisher
	TrÃ©cul A, Morceau F, Gaigneaux A, Schnekenburger M, Dicato M, Diederich M. Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA regulatory micro-networks. Biochem Pharmacol. 2014;92:299-311 pubmed publisher
	Dmitriev R, Pestov N, Shakhparonov M, Okkelman I. Two distinct nuclear localization signals in mammalian MSL1 regulate its function. J Cell Biochem. 2014;115:1967-73 pubmed publisher
	Khair L, Guikema J, Linehan E, Ucher A, Leus N, Ogilvie C, et al. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. J Immunol. 2014;192:4887-96 pubmed publisher
	Gaglio D, D Alfonso A, Camilloni G. Functional complementation of sir2? yeast mutation by the human orthologous gene SIRT1. PLoS ONE. 2013;8:e83114 pubmed publisher
	Schiza V, Molina Serrano D, Kyriakou D, Hadjiantoniou A, Kirmizis A. N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing. PLoS Genet. 2013;9:e1003805 pubmed publisher
	Komatsu T, Nagata K. Replication-uncoupled histone deposition during adenovirus DNA replication. J Virol. 2012;86:6701-11 pubmed publisher
	Mishra P, Au W, Choy J, Kuich P, Baker R, Foltz D, et al. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells. PLoS Genet. 2011;7:e1002303 pubmed publisher
	Revenko A, Kalashnikova E, Gemo A, Zou J, Chen H. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol. 2010;30:5260-72 pubmed publisher

product information

Catalog Number :

04-858

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Histone H4 Antibody, pan, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P62805

Host Name :

Rabbit

Antigen :

Histone H4

Clone :

62-141-13

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Histone H4 Antibody, pan, rabbit monoclonal

Cross Reactivity :

Chicken;Human;Vertebrates;Yeast ( S. cerevisiae )

Background :

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin. The histones have an amino terminal tail, a globular domain, and a carboxy-terminal tail. The four core histones, H2A, H2B, H3 and H4 assemble into the octamer (2 molecules of each). Subsequently, 146 base pairs of DNA are wrapped in a sequence-independent manner around the octamer, forming the basic subunit of chromatin, the nucleosome. Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail, H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure.

ALT Names :

H4;Histone H4

Immunogen :

Synthetic peptide corresponding to amino acids 17-28 of Histone H4. Epitope has been mapped to residues 25-28

Specificity :

Recognizes Histone H4.

Package Size :

100 μL

Uses :

Western Blotting;Multiplexing;Chromatin Immunoprecipitation (ChIP)

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.