TBK1 Antibody, clone AOW9, rabbit monoclonal | EMD Millipore 04-856 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

TBK1 Antibody, clone AOW9, rabbit monoclonal

catalog :

04-856

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

AOW9

reactivity :

human, mouse, dogs, chicken

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human western blot; human	Newman A, Scholefield C, Kemp A, Newman M, McIver E, Kamal A, et al. TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE. 2012;7:e50672 pubmed publisher
	Kim J, Kim Y, Stinski M, Ahn J, Song Y. Human Cytomegalovirus IE2 86 kDa Protein Induces STING Degradation and Inhibits cGAMP-Mediated IFN-Î² Induction. Front Microbiol. 2017;8:1854 pubmed publisher
	Wang Y, Tong X, Ye X. Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation. J Immunol. 2012;189:5304-13 pubmed publisher
	Wang Y, Tong X, Omoregie E, Liu W, Meng S, Ye X. Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. J Biol Chem. 2012;287:34626-34 pubmed publisher

product information

Catalog Number :

04-856

Subcategory :

Cell Signaling

Product Name :

Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q9UHD2

Host Name :

Rabbit

Antigen :

TBK1

Clone :

AOW9

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-TBK1 Antibody, clone AOW9, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Canine;Chicken

Background :

TBK, also known as IκB kinase (IKK)-related kinase NAK, belong to the serine/threonine IKK kinase family and is thought to play a role in NF-kappa-B (NF-κB) activation. The NF-κB complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NF-κB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NF-κB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NF-κB inhibition caused by TANK.

ALT Names :

NF-kB-activating kinase;NF-kappa-B-activating kinase;TANK-binding kinase 1

Immunogen :

Peptide corresponding to the sequence C. EEVS. (amino acids 642-645) of human TANK-binding kinase 1 (TBK1) with an N-terminal cysteine added for conjugation purposes.

Specificity :

TBK1; Does not cross-react with IKKε, IKKα or IKKβ.

Package Size :

100 μL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.