Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal | EMD Millipore 04-820 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal

catalog :

04-820

quantity :

100 μL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

60C

reactivity :

human, mouse, chicken, bovine

application :

western blot, immunoprecipitation, immunohistochemistry - paraffin section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; chicken; fig 6a	Wistedt A, Ridderstråle Y, Wall H, Holm L. Age-related changes in the shell gland and duodenum in relation to shell quality and bone strength in commercial laying hen hybrids. Acta Vet Scand. 2019;61:14 pubmed publisher
western blot; human; loading ...; fig 2a; 2g	Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed publisher
	Lee J, Tiwari A, Shum V, Mills G, Mancini M, Igoshin O, et al. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014;42:6839-49 pubmed publisher
	Bolt M, Stossi F, Callison A, Mancini M, Dandekar R, Mancini M. Systems level-based RNAi screening by high content analysis identifies UBR5 as a regulator of estrogen receptor-? protein levels and activity. Oncogene. 2015;34:154-64 pubmed publisher
	Bolt M, Stossi F, Newberg J, Orjalo A, Johansson H, Mancini M. Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses. Nucleic Acids Res. 2013;41:4036-48 pubmed publisher
	Poulard C, Treilleux I, Lavergne E, Bouchekioua Bouzaghou K, Goddard Leon S, Chabaud S, et al. Activation of rapid oestrogen signalling in aggressive human breast cancers. EMBO Mol Med. 2012;4:1200-13 pubmed publisher

product information

Catalog Number :

04-820

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P03372

Host Name :

Rabbit

Antigen :

Estrogen Receptor α

Clone :

60C

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-Estrogen Receptor α Antibody, clone 60C, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat;Bovine;Pig

Background :

The Estrogen Receptors (ER) belong to the nuclear receptor family that contains a ligand-binding domain that maintains the protein in an inactive conformation unless bound to the hormone. Two ERs are known, ERα, classically known as ER, and ERβ, described long after ERα. Activated Estrogen Receptor is a DNA-binding protein capable of inducing many changes in gene expression. The Estrogen Receptor is believed to play an important role in the growth and development of a subset of hormone dependent human breast cancers. ERβ is expressed in prostate, ovary, and other reproductive organs. Although its steroid specificity is very similar to that of the ERα, the molecular mechanisms regulating the transcriptional activity of ERβ may be distinct from those regulating ERα.

ALT Names :

Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;estrogen receptor 1;estrogen receptor alpha ;oestrogen receptor ;steroid hormone receptor

Immunogen :

KLH-conjugated, synthetic peptide corresponding to amino acids 13-32 (C-ALLHQIQGNELEPLNRPQLK) of human Estrogen Receptor α. The immunizing sequence is identical in rat and mouse and has 19/20 identical amino acids in bovine and porcine.

Specificity :

Recognizes Estrogen Receptor α. No cross-reactivity with Estrogen Receptor β.

Package Size :

100 μL

Uses :

Western Blotting;Immunoprecipitation

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.