SET7/9 Antibody, clone 5F2.3 | EMD Millipore 04-805 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SET7/9 Antibody, clone 5F2.3

catalog :

04-805

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5F2.3

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; human; 1:400 immunoprecipitation; human; 1:150 western blot; human; 1:2000; fig 3	Oppenheimer H, Kumar A, Meir H, Schwartz I, Zini A, Haze A, et al. Set7/9 impacts COL2A1 expression through binding and repression of SirT1 histone deacetylation. J Bone Miner Res. 2014;29:348-60 pubmed publisher
	Hsu C, Peng K, Jhang H, Lin C, Wu S, Chiang C, et al. The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription. Oncogene. 2012;31:2335-49 pubmed publisher
	Gaughan L, Stockley J, Wang N, McCracken S, Treumann A, Armstrong K, et al. Regulation of the androgen receptor by SET9-mediated methylation. Nucleic Acids Res. 2011;39:1266-79 pubmed publisher

product information

Catalog Number :

04-805

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-SET7/9 Antibody, clone 5F2.3

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q8WTS6

Host Name :

Mouse

Antigen :

SET7/9

Clone :

5F2.3

Conjugate :

Purified

Product Description :

Anti-SET7/9 Antibody, clone 5F2.3

Cross Reactivity :

Human;Mouse;Rat

Background :

The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of Histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule, in an unusual conformation, binds a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue.

ALT Names :

SetD7;Histone-lysine N-methyltransferase SETD7 ;EC 2.1.1.43;SET domain-containing protein 7;SET7/9;Histone H3-K4 methyltransferase SETD7;Set7;Set9

Immunogen :

N-terminal His-tagged human SET9 recombinant protein

Specificity :

Recognizes human SET7/9

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.