NFAT1 Antibody, clone 8G4.2 | EMD Millipore 04-804 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NFAT1 Antibody, clone 8G4.2

catalog :

04-804

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8G4.2

reactivity :

human, mouse

application :

western blot, immunocytochemistry

product information

Catalog Number :

04-804

Subcategory :

Cell Signaling

Product Name :

Anti-NFAT1 Antibody, clone 8G4.2

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q13469

Host Name :

Mouse

Antigen :

NFAT1

Clone :

8G4.2

Conjugate :

Purified

Isotype :

IgMκ

Product Description :

Anti-NFAT1 Antibody, clone 8G4.2

Cross Reactivity :

Human;Mouse;Rat

Background :

NFAT (Nuclear Factor of Activated T-cells) is a family of transcription factors that are located in the cytoplasm in their inactive state. NFAT translocates to the nucleus upon stimulation of the T-cell receptor where it plays a key role in gene expression in immune response. NFAT is dephosphorylated and activated by the phosphatase PP2B/Calcineurin. This results in its nuclear localization and transcriptional activity. For NFAT1 (NFATC2, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), calcineurin is known to target the region between residues 114-126. Mutations in this region of NFAT1 result in its inability to de-phosphorylate and subsequent nuclear translocation. Upon activation, NFAT mediates the transcriptional induction of cytokines and other immuno-regulatory genes during immune responses, and is expressed in T-cells, B-cells, mast cells and NK cells.

ALT Names :

NFAT pre-existing subunit ;NFAT transcription complex, preexisting component ;T cell transcription factor NFAT1 ;nuclear factor of activated T-cells, cytoplasmic ;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;nuclear factor of activated T-cells, preexisting component 2 preexisting nuclear factor of activated T-cells 2

Immunogen :

GST-fusion protein corresponding to amino acids 1-297 of human NFAT1.

Specificity :

Detects NFAT1.

Package Size :

100 μg

Uses :

Western Blotting;Immunofluorescence

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.