phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal | EMD Millipore 04-792 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal

catalog :

04-792

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

NL41

reactivity :

human

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:200; fig 1	O Connor A, Maffini S, Rainey M, Kaczmarczyk A, Gaboriau D, Musacchio A, et al. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biol Open. 2015;5:11-9 pubmed publisher
	Recino A, Sherwood V, Flaxman A, Cooper W, Latif F, Ward A, et al. Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis. Biochem J. 2010;430:207-13 pubmed publisher

product information

Catalog Number :

04-792

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P49450

Host Name :

Rabbit

Antigen :

phospho-CENP-A (Ser7)

Clone :

clone NL41

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal

Cross Reactivity :

Human

Background :

Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.

Immunogen :

peptide containing the sequence RRpSRK in which pS is phospho-serine corresponding to amino acid 7 of human CENP-A (centromere protein A)

Specificity :

CENP-A phosphorylated on serine 7

Package Size :

100 µL

Uses :

Multiplexing;Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.